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Review
. 2025 Jul 11;13(7):314.
doi: 10.3390/dj13070314.

Activation of the Nrf2 Signaling Pathway as a Therapeutic Strategy Against Periodontal Disease: A Narrative Review

Sarmistha Saha  1 , Nadezhda Sachivkina  2 , Ekaterina Lenchenko  3 , Olga Pilshchikova  4 , Alexandr Muraev  5
Affiliations
Review

Activation of the Nrf2 Signaling Pathway as a Therapeutic Strategy Against Periodontal Disease: A Narrative Review

Sarmistha Saha et al. Dent J (Basel). .

Abstract

Periodontitis (PD), is a chronic inflammatory disease of the periodontal system, which includes gingiva, periodontal ligament, alveolar bone, and tooth cement. It is becoming increasingly prevalent globally, and its implications for oral health are profound. The Nrf2 signaling pathway is crucial in managing the relationship between inflammation and oxidative stress, making it vital for understanding this disease. Nrf2 interacts with key redox-sensitive inflammatory pathways, playing a vital role in the development of periodontitis. Acknowledging these dynamics underscores the importance of proactively addressing the complex aspects of periodontal disease. This review emphasizes its intricate interactions with redox-sensitive transcription factors vital for sustaining the self-perpetuating inflammatory processes underlying the disease. Additionally, it explores promising therapeutic strategies aimed at Nrf2 activation and encourages more effective management of PD.

Keywords: Nrf2; oxidative stress; periodontitis; pharmacotherapy.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Differentiation between healthy tooth and periodontitis.
Figure 2
Figure 2
Role of Nrf2 activation in periodontitis. The red and black colors indicate positive and negative regulation by Nrf2, respectively.
See this image and copyright information in PMC

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References

    1. Inanc N., Mumcu G., Can M., Yay M., Silbereisen A., Manoil D., Direskeneli H., Bostanci N. Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis. Sci. Rep. 2021;11:2888. doi: 10.1038/s41598-021-82335-9. - DOI - PMC - PubMed
    1. Giannini G., Ragusa I., Nardone G.N., Soldi S., Elli M., Valenti P., Rosa L., Marra E., Stoppoloni D., Pich E.M., et al. Probiotics-containing mucoadhesive gel for targeting the dysbiosis associated with periodontal diseases. Int. J. Dent. 2022;2022:5007930. doi: 10.1155/2022/5007930. - DOI - PMC - PubMed
    1. Rajbhandari P., Shrestha D. Prevalence and associated risk factors of tooth wear. J. Nepal Med. Assoc. 2018;56:719–723. - PMC - PubMed
    1. Trindade D., Carvalho R., Machado V., Chambrone L., Mendes J.J., Botelho J. Prevalence of periodontitis in dentate people between 2011 and 2020: A systematic review and meta-analysis of epidemiological studies. J. Clin. Periodontol. 2023;50:604–626. doi: 10.1111/jcpe.13769. - DOI - PubMed
    1. Caton J.G., Armitage G., Berglundh T., Chapple I.L.C., Jepsen S., Kornman K.S., Mealey B.L., Papapanou P.N., Sanz M., Tonetti M.S. A new classification scheme for periodontal and peri-implant diseases and conditions—Introduction and key changes from the 1999 classification. J. Clin. Periodontol. 2018;45((Suppl. 20)):S1–S8. doi: 10.1111/jcpe.12935. - DOI - PubMed

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