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Review
. 2025 Jul 1;10(7):426.
doi: 10.3390/biomimetics10070426.

Biomimetic Strategies for Nutraceutical Delivery: Advances in Bionanomedicine for Enhanced Nutritional Health

Vicente Javier Clemente-Suárez  1   2 , Alvaro Bustamante-Sanchez  1 , Alejandro Rubio-Zarapuz  1 , Alexandra Martín-Rodríguez  1   3 , José Francisco Tornero-Aguilera  4 , Ana Isabel Beltrán-Velasco  5
Affiliations
Review

Biomimetic Strategies for Nutraceutical Delivery: Advances in Bionanomedicine for Enhanced Nutritional Health

Vicente Javier Clemente-Suárez et al. Biomimetics (Basel). .

Abstract

Background: Biomimetic strategies have gained increasing attention for their ability to enhance the delivery, stability, and functionality of nutraceuticals by emulating natural biological systems. However, the literature remains fragmented, often focusing on isolated technologies without integrating regulatory, predictive, or translational perspectives.

Objective: This review aims to provide a comprehensive and multidisciplinary synthesis of biomimetic and bio-inspired nanocarrier strategies for nutraceutical delivery, while identifying critical gaps in standardization, scalability, and clinical translation.

Results: We present a structured classification matrix that maps biomimetic delivery systems by material type, target site, and bioactive compound class. In addition, we analyze predictive design tools (e.g., PBPK modeling and AI-based formulation), regulatory frameworks (e.g., EFSA, FDA, and GSRS), and risk-driven strategies as underexplored levers to accelerate innovation. The review also integrates ethical and environmental considerations, and highlights emerging trends such as multifunctional hybrid systems and green synthesis routes.

Conclusions: By bridging scientific, technological, and regulatory domains, this review offers a novel conceptual and translational roadmap to guide the next generation of biomimetic nutraceutical delivery systems. It addresses key bottlenecks and proposes integrative strategies to enhance design precision, safety, and scalability.

Keywords: antioxidant nanocarriers; bioavailability enhancement; biogenic nanoparticles; biomimetic delivery; nutraceuticals; targeted nutrient delivery.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Conceptual framework for biomimetic systems.
Figure 2
Figure 2
Classification of biomimetic delivery systems by material type, biological target, and bioactive compound.
See this image and copyright information in PMC

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