Editorial: LAMP Lights the Way-A Pragmatic Case for NUDT15 Screening Across Diverse Populations-Authors' Reply

Chris Roberts^{1

2}, James R Goodhand^{1

2}, Tariq Ahmad^{1

2}

Affiliations

¹ Exeter IBD and Pharmacogenetics Research Group, Exeter, UK.
² Department of Gastroenterology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.

Editorial

Chris Roberts et al. Aliment Pharmacol Ther. 2025 Sep.

. 2025 Sep;62(6):670-671.

doi: 10.1111/apt.70289. Epub 2025 Jul 25.

Chris Roberts^{1

2}, James R Goodhand^{1

2}, Tariq Ahmad^{1

2}

¹ Exeter IBD and Pharmacogenetics Research Group, Exeter, UK.
² Department of Gastroenterology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.

No abstract available

Keywords: genomics; immunosuppression; inflammation; inflammatory bowel disease; thiopurines.

References

1. S. A. V. Shah and D. Desai, “Editorial: LAMP Lights the Way – A Pragmatic Case for NUDT15 Screening Across Diverse Populations,” Alimentary Pharmacology & Therapeutics 62 no. 6 (2025): 668–669.
1. C. Roberts, J. Peters, A. Sazonvos, et al., “Clinical Utility and Cost‐Effectiveness of Pretreatment NUDT15 Pharmacogenetic Testing to Prevent Thiopurine‐Induced Myelosuppression: A Genotype‐First Reverse Phenotyping Cohort Study Within the UK NIHR Inflammatory Bowel Disease Bioresource,” Alimentary Pharmacology & Therapeutics 62 no. 6 (2025): 630–645.
1. K. Zarca, A. Chansavang, M. A. Loriot, I. Durand‐Zaleski, and N. Pallet, “Cost‐Effectiveness Analysis of Pretreatment Screening for NUDT15 Defective Alleles,” Pharmacogenetics and Genomics 30 (2020): 175–183.
1. D. Zeng, X. Huang, S. Lin, R. Lin, X. Weng, and P. Huang, “Cost‐Effectiveness Analysis of Genotype Screening and Therapeutic Drug Monitoring in Patients With Inflammatory Bowel Disease Treated With Azathioprine Therapy: A Chinese Healthcare Perspective Using Real‐World Data,” Annals of Translational Medicine 9 (2021): 1138.
1. M. V. Relling, M. Schwab, M. Whirl‐Carrillo, et al., “Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update,” Clinical Pharmacology and Therapeutics 105 (2019): 1095–1105, https://doi.org/10.1002/cpt.1304.