Keratin 20 Suppresses Exosomal Secretion of Peroxiredoxin 2 and Ferroptosis in Acute Kidney Injury

Lijun Yin^{1

2}, Zebin Deng^{1

2

3}, Jiachen Liu⁴, Lin Ye^{1

2}, Jun Huang³, Yingbo Dai⁵, Yinhuai Wang³, Yu Li⁶, Xuejing Zhu^{1

2}, Yu Lu^{1

7}, Yong Wu^{1

2}, Baiyu Feng^{1

2}, Yunhui He^{1

2

3}, Dongshan Zhang⁸, Shaobin Duan^{1

2}, Zheng Dong⁹, Fei Deng^{1

2

3}, Anqun Chen^{1

2

10

11}

Affiliations

¹ Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, China.
² Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, China.
³ Department of Urology, The Second Xiangya Hospital of Central South University, Changsha, China.
⁴ The Center of Systems Biology and Data Science, School of Basic Medical Science, Central South University, Changsha, China.
⁵ Department of Urology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China.
⁶ Division of Nephrology, Zhongshan Hospital, Xiamen University, Xiamen, China.
⁷ Department of Epidemiology and Biostatistics, Boston University School of Public Health, Boston, Massachusetts.
⁸ Department of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha, China.
⁹ Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia.
¹⁰ Furong Laboratory, Changsha, China.
¹¹ National Clinical Research Center for Metabolic Diseases, The Second Xiangya Hospital of Central South University, Changsha, China.

PMID: 40711819
DOI: 10.1681/ASN.0000000805

Keratin 20 Suppresses Exosomal Secretion of Peroxiredoxin 2 and Ferroptosis in Acute Kidney Injury

Lijun Yin et al. J Am Soc Nephrol. 2025.

. 2025 Jul 25.

doi: 10.1681/ASN.0000000805. Online ahead of print.

Authors

Affiliations

¹ Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, China.
² Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, China.
³ Department of Urology, The Second Xiangya Hospital of Central South University, Changsha, China.
⁴ The Center of Systems Biology and Data Science, School of Basic Medical Science, Central South University, Changsha, China.
⁵ Department of Urology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China.
⁶ Division of Nephrology, Zhongshan Hospital, Xiamen University, Xiamen, China.
⁷ Department of Epidemiology and Biostatistics, Boston University School of Public Health, Boston, Massachusetts.
⁸ Department of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha, China.
⁹ Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia.
¹⁰ Furong Laboratory, Changsha, China.
¹¹ National Clinical Research Center for Metabolic Diseases, The Second Xiangya Hospital of Central South University, Changsha, China.

PMID: 40711819
DOI: 10.1681/ASN.0000000805

No abstract available

Keywords: AKI; cell death.

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References

1. Birkelo BC, Pannu N, Siew ED. Overview of diagnostic criteria and epidemiology of acute kidney injury and acute kidney disease in the critically ill patient. Clin J Am Soc Nephrol. 2022;17(5):717–735. doi: 10.2215/CJN.14181021 - DOI
1. Cao J-Y, Wang B, Tang T-T, et al. Exosomal miR-125b-5p deriving from mesenchymal stem cells promotes tubular repair by suppression of p53 in ischemic acute kidney injury. Theranostics. 2021;11(11):5248–5266. doi: 10.7150/thno.54550 - DOI
1. Wen Y, Parikh CR. Current concepts and advances in biomarkers of acute kidney injury. Crit Rev Clin Lab Sci. 2021;58(5):354–368. doi: 10.1080/10408363.2021.1879000 - DOI
1. Kellum JA, Prowle JR. Paradigms of acute kidney injury in the intensive care setting. Nat Rev Nephrol. 2018;14(4):217–230. doi: 10.1038/nrneph.2017.184 - DOI
1. Wang L, Shang Y, Zhang J, Yuan J, Shen J. Recent advances in keratin for biomedical applications. Adv Colloid Interf Sci. 2023;321:103012. doi: 10.1016/j.cis.2023.103012 - DOI

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Keratin 20 Suppresses Exosomal Secretion of Peroxiredoxin 2 and Ferroptosis in Acute Kidney Injury

Affiliations

Keratin 20 Suppresses Exosomal Secretion of Peroxiredoxin 2 and Ferroptosis in Acute Kidney Injury

Authors

Affiliations

References

Grants and funding

LinkOut - more resources

Full Text Sources

Research Materials