Early postnatal management of neonatal RBC alloimmunization

Abstract

Hemolytic disease of the newborn (HDN) remains a significant clinical challenge in neonatal care. This review focuses on the early postnatal management of HDN and synthesizes current evidence-based recommendations to guide healthcare professionals in optimizing outcomes for affected neonates. Key areas of discussion include the diagnosis and monitoring of HDN, the management of hyperbilirubinemia, and the use of immunoglobulin therapy and exchange transfusion and transfusion policy. Practical challenges such as resource limitations, timely diagnosis, and the implementation of standardized protocols are highlighted. The review aims to provide a comprehensive overview of the latest evidence to support clinicians in making informed decisions in the management of HDN.

Keywords: Anemia; Exchange transfusion; Hemolytic disease of the newborn; Hyperbilirubinemia; Phototherapy.