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. 2025 Jul 26.
doi: 10.1111/odi.70044. Online ahead of print.

Endometriosis-Associated Periodontal Disease: A Large Cohort Perspective Study

Maria Teresa Agneta  1   2 , Giuseppe D'Albis  2 , Letizia Lorusso  3 , Nicola Bartolomeo  2 , Antonia Abbinante  1   2 , Anna Antonacci  1   2 , Pietro Signorile  4 , Francesco D'Aiuto  5 , Elisa Mazza  6   7 , Massimo Corsalini  2 , Saverio Capodiferro  2
Affiliations

Endometriosis-Associated Periodontal Disease: A Large Cohort Perspective Study

Maria Teresa Agneta et al. Oral Dis. .

Abstract

Objective: Endometriosis is a chronic estrogen-dependent gynecological disease affecting millions of women worldwide. Besides its well-established impact on reproductive health, emerging evidence suggests a potential association between endometriosis and periodontal disease. The present study discusses the interplay between the two diseases, exploring shared immunopathological mechanisms, including chronic inflammation, hormonal imbalance, and immune system modulation.

Materials and methods: A 45-question standardized questionnaire was answered by 4072 women clinically diagnosed with endometriosis to identify self-reported periodontal status, oral hygiene habits, and systemic symptoms.

Results: Findings report that more severe stages of endometriosis are related to increased awareness of periodontal disease, greater gingival bleeding, xerostomia, and mucosal alterations. Moreover, greater diagnostic latency aggravates both systemic and oral disorders, supporting the necessity of early treatment. These findings highlight the need for a single, multidisciplinary standard of patient care involving gynecologists, dentists, dental hygienists, and other healthcare providers.

Conclusion: By connecting gynecological and dental care, this study aims to promote awareness, facilitate early diagnosis, and improve quality of life for women suffering from endometriosis. Future research must explore mechanisms linking the conditions and assess therapeutic approaches to alleviate oral health issues in these individuals.

Keywords: chronic inflammation; endometriosis; multidisciplinary care; oral‐systemic connection; periodontal disease.

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References

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