Editorial Expression of Concern: Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation

Affiliations

¹ Department of Demyelinating Disease and Aging, National Institute of Neuroscience, NCNP, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan.
² Fuji Gotemba Research Labs, Chugai Pharmaceutical, 1-135 Komakado, Gotemba, Shizuoka, 412-8531, Japan.
³ Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, Valbonne, 06560, France.
⁴ Department of Neurosurgery, University Medical School of Pécs, Pécs, Hungary.
⁵ Department of Demyelinating Disease and Aging, National Institute of Neuroscience, NCNP, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan. tabira@ncnaxp.ncnp.go.jp.

De-Hua Chui et al. Nat Med. 2025 Aug.

. 2025 Aug;31(8):2821.

doi: 10.1038/s41591-025-03903-4.

¹ Department of Demyelinating Disease and Aging, National Institute of Neuroscience, NCNP, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan.
² Fuji Gotemba Research Labs, Chugai Pharmaceutical, 1-135 Komakado, Gotemba, Shizuoka, 412-8531, Japan.
³ Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, Valbonne, 06560, France.
⁴ Department of Neurosurgery, University Medical School of Pécs, Pécs, Hungary.
⁵ Department of Demyelinating Disease and Aging, National Institute of Neuroscience, NCNP, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan. tabira@ncnaxp.ncnp.go.jp.

No abstract available

Expression of concern for

Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.
Chui DH, Tanahashi H, Ozawa K, Ikeda S, Checler F, Ueda O, Suzuki H, Araki W, Inoue H, Shirotani K, Takahashi K, Gallyas F, Tabira T. Chui DH, et al. Nat Med. 1999 May;5(5):560-4. doi: 10.1038/8438. Nat Med. 1999. PMID: 10229234