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. 2025 Jul 11:5:104319.
doi: 10.1016/j.bas.2025.104319. eCollection 2025.

Consensus on the management of traumatic brain injury in older adults: Results from a Delphi study

Collaborators, Affiliations

Consensus on the management of traumatic brain injury in older adults: Results from a Delphi study

Alfonso Lagares et al. Brain Spine. .

Abstract

Introduction: As the world population is rapidly becoming older, the incidence of traumatic brain injury (TBI) is increasing among older adults with vast implications for brain health of older adults in Europe. Due to differences from younger patients, there are areas of uncertainty in the assessment, diagnosis and management of TBI in older adults.

Research question: To reach a consensus among experts on statements regarding the definition of old age, assessment, diagnosis and management of traumatic brain injury in older adults.

Materials and methods: A modified Delphi method consisting of two online rounds was organised, followed by an in-person meeting. Consensus was defined as >75 % agreement. In the second online round the experts were able to view their first assessment and the average of the group. Some statements were rephrased and presented again in the in-person meeting. Questions with numerical data could not be assessed by consensus and descriptive and non-parametric statistics were used to analyze them.

Results: Experts (n = 72), from different nationalities (Europe, United States, Latin America, Africa and Asia) and specialities (Neurosurgery, Emergency Medicine, Intensive care medicine) responded on 62 statements. Consensus was finally reached on 44 statements regarding the definition of older adulthood, as well as the assessment, surgical and intensive care management, discharge, and rehabilitation of patients.

Discussion and conclusions: This consensus reinforces the importance of this area for physicians and researchers interested in traumatic brain injury. It signals important areas of agreement as well as future topics for research and specific knowledge gaps.

Keywords: Aged; Clinical management; Diagnosis; Outcome; Traumatic brain injury; consensus.

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Conflict of interest statement

The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Alfonso Lagares reports a relationship with bioMérieux SA that includes: consulting or advisory. Jussi Posti reports a relationship with Sanofi SA that includes: consulting or advisory. Jussi Posti reports a relationship with Finnish Medical Association that includes: consulting or advisory. Jussi Posti reports a relationship with National Institute of Neurological Disorders and Stroke that includes: travel reimbursement. Jussi Posti reports a relationship with Wellbeing services counti of North Karelia that includes: consulting or advisory. Jussi Posti reports a relationship with Finnish Association of Otorhinolaryngology that includes: consulting or advisory. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Overview of the 4 round Delphi study process.
Fig. 2
Fig. 2
Summary of statements in which consensus was obtained.
Fig. 3
Fig. 3
Quantitative age limits for definition of older adult age and surgical treatment.

References

    1. Brazinova A., Rehorcikova V., Taylor M.S., Buckova V., Majdan M., Psota M., Peeters W., Feigin V., Theadom A., Holkovic L., Synnot A. Epidemiology of traumatic brain injury in Europe: a living systematic review. J. Neurotrauma. 2021;38:1411–1440. doi: 10.1089/neu.2015.4126. - DOI - PMC - PubMed
    1. Calluy E., Beaudart C., Alokail M.S., Al-Daghri N.M., Bruyère O., Reginster J.-Y., Cavalier E., Ladang A. Confounding factors of the expression of mTBI biomarkers, S100B, GFAP and UCH-L1 in an aging population. Clin. Chem. Lab. Med. 2024;62:2062–2069. doi: 10.1515/cclm-2024-0194. - DOI - PubMed
    1. Castaño-Leon A.M., Gomez P.A., Jimenez-Roldan L., Paredes I., Munarriz P.M., Delgado-Fernandez J., Panero Perez I., Moreno Gomez L.M., Esteban Sinovas O., Garcia Posadas G., Maldonado Luna M., Baciu A.E., Lagares A. The impact of early surgery on mortality and functional recovery in older adults with traumatic intracranial lesions: a propensity score-based analysis. Acta Neurochir. 2024;166:443. doi: 10.1007/s00701-024-06324-3. - DOI - PubMed
    1. Cepeda S., Gómez P.A., Castaño-Leon A.M., Martínez-Pérez R., Munarriz P.M., Lagares A. Traumatic intracerebral hemorrhage: risk factors associated with progression. J. Neurotrauma. 2015;32 doi: 10.1089/neu.2014.3808. - DOI - PubMed
    1. Cheung A., Haas B., Ringer T.J., McFarlan A., Wong C.L. Canadian study of health and aging clinical frailty scale: does it predict adverse outcomes among geriatric trauma patients? J. Am. Coll. Surg. 2017;225:658–665.e3. doi: 10.1016/j.jamcollsurg.2017.08.008. - DOI - PubMed

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