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. 2025 Jul-Sep;16(3):162-165.
doi: 10.4103/picr.picr_179_25. Epub 2025 Jul 8.

Measuring quality of life in clinical research - Part 1

Priya Ranganathan  1 , Jammbe Z Musoro  2 , C S Pramesh  3
Affiliations

Measuring quality of life in clinical research - Part 1

Priya Ranganathan et al. Perspect Clin Res. 2025 Jul-Sep.

Abstract

Health-related quality of life (HRQOL) is increasingly being recognized as an important outcome for individuals, both as part of clinical care as well as in research, along with conventional outcomes like response or survival. HRQOL includes several domains of functioning and is complex and difficult to measure. In this series of articles, we examine the concept of HRQOL and methods to measure it.

Keywords: HRQOL; Health-related quality of life; quality of life.

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Conflict of interest statement

There are no conflicts of interest.

References

    1. Karimi M, Brazier J. Health, health-related quality of life,and quality of life:What is the difference? Pharmacoeconomics. 2016;34:645–9. - PubMed
    1. Hays RD, Reeve BB. Measurement and modelingof health-related quality of life. In: Killewo J, Heggenhougen HK, Quah SR, editors. Epidemiology and Demography in Public Health. San Diego: Academic Press; 2010. pp. 195–205.
    1. Pe M, Voltz-Girolt C, Bell J, Bhatnagar V, Bogaerts J, Booth C, et al. Using patient-reported outcomes and health-related quality of life data in regulatory decisions on cancer treatment:Highlights from an EMA-EORTC workshop. Lancet Oncol. 2025;26:687–90. - PubMed
    1. Coons SJ, Rao S, Keininger DL, Hays RD. A comparative review of generic quality-of-life instruments. Pharmacoeconomics. 2000;17:13–35. - PubMed
    1. [[Last accessed on 2025 Jun 06]]. Available from: https://www.rand.org/health-care/surveys_tools/mos/36-item-short-form.html .

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