Serum Wnt1-Inducible signalling pathway Protein-1 levels are associated with cerebral infarction in patients with type 2 diabetes mellitus

Abstract

Purpose: To investigate the correlation between serum Wnt1-inducible signalling pathway protein-1 (WISP-1) levels and cerebral infarction (CI) in patients with type 2 diabetes (T2DM).

Methods: This was a cross-sectional study. We enrolled 87 patients with T2DM (T2DM group) and 83 T2DM patients with cerebral infarction (DCI group) who were admitted to the First Affiliated Hospital of Soochow University. Serum WISP-1 levels were assessed via an enzyme-linked immunosorbent assay (ELISA). Differences in general statistics, biochemical parameters, islet function, and serum WISP-1 levels were compared between the two groups. The associations between the WISP-1 levels and other parameters and the influences of various parameters on the risk of cerebral infarction were analysed.

Results: The level of WISP-1 in the DCI group (204.87 ± 32.02 pg/ml) was greater than that in the T2DM group (191.57 ± 33.36 pg/ml) (p < 0.05). Multiple logistic regression analysis revealed that the WISP-1 level, age and HDL-C level were independent factors associated with the occurrence of cerebral infarction in T2DM patients (p < 0.05 and p < 0.01, respectively). The area under the ROC curve of serum WISP-1, age and HDL-C for CI in T2DM patients was 0.797 (0.731-0.863, p < 0.01). Spearman correlation analysis revealed that the WHR and HbA1c, Cr and VitD levels were positively correlated with serum WISP-1 levels (r = 0.237, r = 0.153, r = 0.165 and r = 0.164, respectively, p < 0.05) and that the WHR and HbA1c and VitD levels were independently correlated with WISP-1.

Conclusion: A high WISP-1 level is an independent risk factor for cerebral infarction in T2DM patients. WISP-1 levels are affected by the WHR and HbA1c and VitD levels.

Keywords: Cerebral infarction; Risk factor; Type 2 diabetes; WISP-1.