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Comment
. 2025 Oct 1;32(6):taaf076.
doi: 10.1093/jtm/taaf076.

Revisiting the efficacy of bismuth subsalicylate for the prevention of traveller's diarrhoea

Roger D Gibb  1 , Jose M Brum  2 , Kyle J Sloan  3 , Adam M Pitz  3 , Benjamin T Circello  3 , Rowan A Grayling  3
Affiliations
Comment

Revisiting the efficacy of bismuth subsalicylate for the prevention of traveller's diarrhoea

Roger D Gibb et al. J Travel Med. .

Abstract

What can be concluded from a clinical trial that spanned 5 years yet failed to achieve target enrollment, generated flat results that contradict the existing body of knowledge and has a primary efficacy endpoint confounded by a treatment-by-COVID interaction? Could it be a false negative finding?

Trial registration: ClinicalTrials.gov NCT03535272.

Keywords: Bismuth subsalicylate; traveller’s diarrhoea.

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Conflict of interest statement

The authors are employees of The Procter and Gamble Company, the manufacturer of bismuth subsalicylate under the branded name Pepto Bismol.

Figures

Figure 1
Figure 1
Graphical representation of historical and Angelo et al. traveller’s diarrhoea data
See this image and copyright information in PMC

Comment on

References

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