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Review
. 2025 Jul 21;15(14):1830.
doi: 10.3390/diagnostics15141830.

Deep Learning Network Selection and Optimized Information Fusion for Enhanced COVID-19 Detection: A Literature Review

Affiliations
Review

Deep Learning Network Selection and Optimized Information Fusion for Enhanced COVID-19 Detection: A Literature Review

Olga Adriana Caliman Sturdza et al. Diagnostics (Basel). .

Abstract

The rapid spread of COVID-19 increased the need for speedy diagnostic tools, which led scientists to conduct extensive research on deep learning (DL) applications that use chest imaging, such as chest X-ray (CXR) and computed tomography (CT). This review examines the development and performance of DL architectures, notably convolutional neural networks (CNNs) and emerging vision transformers (ViTs), in identifying COVID-19-related lung abnormalities. Individual ResNet architectures, along with CNN models, demonstrate strong diagnostic performance through the transfer protocol; however, ViTs provide better performance, with improved readability and reduced data requirements. Multimodal diagnostic systems now incorporate alternative methods, in addition to imaging, which use lung ultrasounds, clinical data, and cough sound evaluation. Information fusion techniques, which operate at the data, feature, and decision levels, enhance diagnostic performance. However, progress in COVID-19 detection is hindered by ongoing issues stemming from restricted and non-uniform datasets, as well as domain differences in image standards and complications with both diagnostic overfitting and poor generalization capabilities. Recent developments in COVID-19 diagnosis involve constructing expansive multi-noise information sets while creating clinical process-oriented AI algorithms and implementing distributed learning protocols for securing information security and system stability. While deep learning-based COVID-19 detection systems show strong potential for clinical application, broader validation, regulatory approvals, and continuous adaptation remain essential for their successful deployment and for preparing future pandemic response strategies.

Keywords: artificial intelligence; chest X-ray; computer tomography; convolutional neural networks; diagnosis; image classification; medical image analysis; vision transformers.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
DL model for the classification of COVID-19 based on an image dataset (The arrows illustrate the sequence of steps within the workflow).

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