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. 2025 Jul 9;14(14):4857.
doi: 10.3390/jcm14144857.

Comparative Analysis of Descemet Membrane Endothelial Keratoplasty (DMEK) Versus Descemetorhexis Without Keratoplasty (DSO) in Patients with Fuchs Endothelial Corneal Dystrophy

Vanesa Díaz-Mesa  1 , Álvaro Sánchez-Ventosa  1 , Timoteo González-Cruces  1 , Alberto Membrillo  1   2 , Marta Villalba-González  1 , Alberto Villarrubia  1 , Antonio Cano-Ortiz  1   3   4
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Comparative Analysis of Descemet Membrane Endothelial Keratoplasty (DMEK) Versus Descemetorhexis Without Keratoplasty (DSO) in Patients with Fuchs Endothelial Corneal Dystrophy

Vanesa Díaz-Mesa et al. J Clin Med. .

Abstract

Background/Objectives: This retrospective observational study evaluates the efficacy of Descemetorhexis without Keratoplasty (DSO) compared to Descemet Membrane Endothelial Keratoplasty (DMEK) in the management of Fuchs Endothelial Corneal Dystrophy (FECD). The outcomes were compared in terms of the corneal anatomical changes, visual results, and complication rates between the two surgical techniques for FECD. Methods: We conducted a retrospective, descriptive, observational study including 31 eyes from 26 patients who underwent either DSO (n = 16) or DMEK (n = 15) at the Department of Ophthalmology, Hospital Arruzafa. Patients were included if they had complete follow-up data at baseline, 6 months, and 1 year post-intervention. Their clinical information was collected from medical records and complementary tests, including the Snellen visual acuity test, Pentacam corneal tomography, and specular microscopy. Results: The average time to achieve best corrected distance visual acuity (CDVA) was significantly longer for DSO (7.44 ± 2.3 months) than for DMEK (5.73 ± 1.9 months, p = 0.004). Complication rates were higher in the DMEK group (26.7%), and in comparison, there was an absence of complications in the DSO group (p = 0.043). Corneal endothelial cell migration was confirmed in patients who underwent DSO, with a mean cell density of 817.17 ± 91.7 cells/mm2 after one year. Conclusions: DSO effectively treated the selected patients with FECD who presented central guttata and corneal edema, achieving visual outcomes equivalent to those of DMEK while reducing complication rates. This technique eliminates the need for donor tissue and immunosuppressive medications, making it a viable alternative for specific cases.

Keywords: DMEK; DSO; cornea; descemetorhexis; fuchs dystrophy.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Time to achieve the best CDVA between DMEK and DSO. ** Statistically significant differences.
Figure 2
Figure 2
Cell count per mm2 in DMEK vs. DSO. *** Statistically significant differences.
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