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Review
. 2025 Jul 17;14(14):5080.
doi: 10.3390/jcm14145080.

Management of Myeloproliferative Neoplasms: An Integrative Approach

Francesca Andreazzoli  1   2 , Ilana Levy Yurkovski  3   4 , Krisstina Gowin  5 , Massimo Bonucci  2
Affiliations
Review

Management of Myeloproliferative Neoplasms: An Integrative Approach

Francesca Andreazzoli et al. J Clin Med. .

Abstract

Myeloproliferative neoplasms (MPNs) are chronic blood cancers characterized by overproduction of blood cells, leading to increased thrombotic and ischemic risk. Patients frequently experience symptoms including fatigue, abdominal discomfort, and complications from thrombotic events, which significantly impact the quality of life (QoL). Many patients inquire about complementary and integrative medicine (CIM) approaches, including nutritional interventions and supplements, creating opportunities for healthcare providers to engage in meaningful discussions guided by the principle of safety. This review examines the current evidence for integrative approaches in MPN management, focusing on nutrition, microbiota, supplements, mind-body techniques, and acupuncture. We analyze the available data on anti-inflammatory interventions, QoL improvement strategies, and treatment tolerance enhancement. The review provides clinicians with evidence-based guidance for safely integrating complementary therapeutic approaches with conventional MPN treatment. This integrative approach represents an opportunity to develop more comprehensive and personalized therapeutic paradigms in hematology while ensuring that complementary interventions serve as adjuncts to evidence-based medical treatment.

Keywords: acupuncture; integrative hematology; microbiota; mind–body therapies; myeloproliferative neoplasms.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
A potential integrative approach in MPNs.
See this image and copyright information in PMC

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