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. 2025 Jul 28:9:e71923.
doi: 10.2196/71923.

Generative AI-Powered Mental Wellness Chatbot for College Student Mental Wellness: Open Trial

Jazmin A Reyes-Portillo #  1 , Amy So #  1 , Kelsey McAlister #  2 , Christine Nicodemus  3 , Ashleigh Golden #  3 , Colleen Jacobson #  4 , Jennifer Huberty #  2
Affiliations

Generative AI-Powered Mental Wellness Chatbot for College Student Mental Wellness: Open Trial

Jazmin A Reyes-Portillo et al. JMIR Form Res. .

Abstract

Background: Colleges have turned to digital mental health interventions to meet the increasing mental health treatment needs of their students. Among these, chatbots stand out as artificial intelligence-driven tools capable of engaging in human-like conversations that have demonstrated some effectiveness in reducing depression and anxiety symptoms.

Objective: This study aimed to assess the feasibility and acceptability of using Wayhaven, an artificial intelligence chatbot, among college students with elevated depression or anxiety symptoms. We also aimed to examine the preliminary effectiveness of Wayhaven in improving symptoms of anxiety and depression, hopelessness, agency, and self-efficacy among students.

Methods: Participants were 50 racially and ethnically diverse college students with elevated depression or anxiety symptoms (n=45, 80% female; mean age 22.12, SD 4.42 years). Students were asked to use Wayhaven over the course of 1 week and completed assessments at preintervention, after 1 session, and 1 week.

Results: Wayhaven use was associated with a significant decrease in depression (β=-1.62; P<.001), anxiety (β=-2.15; P<.001), and hopelessness (β=-.64; P<.001) and a significant increase in agency (β=.64; P=.32), self-efficacy (β=.53; P=.02), and well-being (t40=2.90; P=.006; d=0.45) across the study period. Most students also reported being satisfied with Wayhaven and it being a tool they would recommend to their peers.

Conclusions: Findings suggest that Wayhaven may be a viable mental wellness resource for diverse students with elevated depression or anxiety symptoms.

Keywords: anxiety; artificial intelligence; chatbots; college students; depression.

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Conflict of interest statement

Conflicts of Interest: CN and AG are employees of Wayhaven. JAR-P, JH, and CJ serve on the Wayhaven advisory board. CJ owns shares of Wayhaven stock. None of the authors was paid for the results of the study.

Figures

Figure 1.
Figure 1.. Example student conversations with the Wayhaven AI mental wellness coach. AI: artificial intelligence.
See this image and copyright information in PMC

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