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Review
. 2025 Jul 5:45:311-316.
doi: 10.1016/j.jpra.2025.06.022. eCollection 2025 Sep.

Research progress of liposomal bupivacaine and its value in perioperative pain management

Hongli Sun  1 , Yapeng Lu  1 , Yingbin Wang  1
Affiliations
Review

Research progress of liposomal bupivacaine and its value in perioperative pain management

Hongli Sun et al. JPRAS Open. .

Abstract

In current pain management practices, multimodal analgesia strategies centered on regional nerve blocks, combined with low-dose opioids and adequate nonsteroidal anti-inflammatory drugs, are considered the standard approach. However, the short-lived effectiveness of conventional local anesthetics leads to inadequate postoperative pain management, which substantially diminishes patient comfort and satisfaction during recovery periods. Prolonging the duration of local anesthetics has become a core focus of regional anesthesia research, with liposomal bupivacaine gaining attention due to its ultra-long-acting properties. This article aims to systematically explore the mechanism of action, safety, potential adverse reactions, and clinical applications of liposomal bupivacaine in nerve blocks and surgical procedures, providing a scientific basis for optimizing clinical analgesia strategies.

Keywords: Liposomal bupivacaine; Perioperative pain management; Regional nerve block.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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