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Review
. 2023 Sep 22;6(4):45.
doi: 10.3390/reports6040045.

COVID-19-Omics Report: From Individual Omics Approaches to Precision Medicine

Irina Vlasova-St Louis  1   2 , Daniel Fang  2 , Yara Amer  3 , Hesham Mohei  4
Affiliations
Review

COVID-19-Omics Report: From Individual Omics Approaches to Precision Medicine

Irina Vlasova-St Louis et al. Reports (MDPI). .

Abstract

During the COVID-19 pandemic, it became apparent that precision medicine relies heavily on biological multi-omics discoveries. High throughput omics technologies, such as host genomics, transcriptomics, proteomics, epigenomics, metabolomics/lipidomics, and microbiomics, have become an integral part of precision diagnostics. The large number of data generated by omics technologies allows for the identification of vulnerable demographic populations that are susceptible to poor disease outcomes. Additionally, these data help to pinpoint the omics-based biomarkers that are currently driving advancements in precision and preventive medicine, such as early diagnosis and disease prognosis, individualized treatments, and vaccination. This report summarizes COVID-19-omic studies, highlights the results of completed and ongoing omics investigations in individuals who have experienced severe disease outcomes, and examines the impact that repurposed/novel antiviral drugs, targeted immunotherapeutics, and vaccines have had on individual and public health.

Keywords: COVID-19 pandemic; acute respiratory distress syndrome (ARDS); epigenomics; genomics; immune responses to SARS-CoV-2; metabolomics; microbiomics; precision and preventive medicine; proteomics; public health; transcriptomics.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Contribution of individual omics disciplines (outlined in hexagons) to population-centric precision medicine and preventive medicine innovation. Data collected from various individual omics technologies provide comprehensive information (depicted by arrows) to allow for the identification of novel biomarkers, signatures, pathways, profiles, and networks (precision diagnostics). Omics technologies have become a part of precision diagnostic medicine, customizing population-centric treatments (precision medicine) and leading to novel vaccine development (preventive medicine).
See this image and copyright information in PMC

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