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Randomized Controlled Trial
. 2025 Jul 18;61(7):1299.
doi: 10.3390/medicina61071299.

The Effects of 8-Week Hydrogen-Rich Water Consumption on Appetite, Body Composition, Sleep Quality, and Circulating Glucagon-like Peptide-1 in Obese Men and Women (HYDRAPPET): A Randomized Controlled Trial

Nikola Todorovic  1 , Sonja Baltic  1 , David Nedeljkovic  1 , Jovan Kuzmanovic  1 , Darinka Korovljev  1 , Dejan Javorac  1 , Katarina Bijelic  2 , Nebojsa Kladar  2 , Alex Tarnava  3 , Sergej M Ostojic  1   4   5
Affiliations
Randomized Controlled Trial

The Effects of 8-Week Hydrogen-Rich Water Consumption on Appetite, Body Composition, Sleep Quality, and Circulating Glucagon-like Peptide-1 in Obese Men and Women (HYDRAPPET): A Randomized Controlled Trial

Nikola Todorovic et al. Medicina (Kaunas). .

Abstract

Background and Objectives: Preliminary studies indicate that dihydrogen (H2) may affect molecular pathways involved in appetite regulation; however, its role in influencing patient-reported appetite outcomes in individuals with obesity remains uncertain. This randomized, placebo-controlled, double-blind trial aimed to evaluate the effects of H2 supplementation on appetite, body composition, sleep quality, obesity-specific quality of life, and related biomarkers in obese men and women. Materials and Methods: The study included 36 participants (24 females; age 42.1 ± 13.2 years; BMI 30.8 ± 4.2 kg/m2) randomized to receive either 1.0 L of hydrogen-rich water (15 mg of H2) or 1.0 L of control water (0 mg of H2) daily for eight weeks. Results: The results demonstrated that hydrogen-rich water significantly mitigated cravings (p = 0.05), improved subjective sleep quality (p = 0.05), reduced total cholesterol (p = 0.02) and LDL cholesterol (p = 0.04), and increased plasma glucagon-like peptide-1 levels (p = 0.05) compared to the control. No severe adverse effects were reported throughout the trial. Conclusions: These findings suggest that hydrogen-rich water may serve as a safe and effective dietary strategy to address appetite regulation and related metabolic indices in individuals with obesity. The study is registered at ClinicalTrials.gov (NCT06722326).

Keywords: GLP-1; cholesterol; cravings; dihydrogen; sleep; supplementation.

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Conflict of interest statement

N.T., S.B., D.N., J.K., D.K., D.J., K.B., N.K., and S.M.O. declare they have no competing interests. A.T. is employed by Natural Wellness Now Health Products Inc., the company that supplied the supplements examined in this study.

Figures

Figure 1
Figure 1
Flow of participants during the study.
See this image and copyright information in PMC

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