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Comment
. 2025 Jul 15:12:1611404.
doi: 10.3389/fcvm.2025.1611404. eCollection 2025.

Commentary: The ETP-based APC resistance assay remains the gold standard for evaluating the APC resistance phenotype in users of combined oral contraceptives

Laure Morimont  1   2 , Jonathan Douxfils  1   2   3
Affiliations
Comment

Commentary: The ETP-based APC resistance assay remains the gold standard for evaluating the APC resistance phenotype in users of combined oral contraceptives

Laure Morimont et al. Front Cardiovasc Med. .
No abstract available

Keywords: ETP-based APC resistance assay; activated protein C (APC); activated protein C resistance; combined oral contraceptives (COC); endogenous thrombin potential (ETP); thrombomodulin (TM).

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Conflict of interest statement

Author LM was employed by the company Qualiblood sa. JD is the founder of Qualiblood sa, a company involved in the development and validation of the ETP-based activated protein C resistance assay. JD received consultancy fees from Gedeon Richter, Estetra, and Mithra Pharmaceuticals. The authors declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Comment on

References

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    1. Douxfils J, Morimont L, Delvigne A-S, Devel P, Masereel B, Haguet H, et al. Validation and standardization of the ETP-based activated protein C resistance test for the clinical investigation of steroid contraceptives in women: an unmet clinical and regulatory need. Clin Chem Lab Med. (2020) 58(2):294–305. 10.1515/cclm-2019-0471 - DOI - PubMed

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