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. 2025 Mar-Apr;40(2):115-116.
doi: 10.4103/ijnm.ijnm_126_24. Epub 2025 Jun 27.

68Ga-PSMA PET/CT in a case of recurrent Glioblastoma

Arunachalam Raghupathi Vishnu  1 , Nishikant Avinash Damle  1 , Kunhi Parambath Haresh  2 , Madhavi Tripathi  1 , G B Priyanka  1
Affiliations

68Ga-PSMA PET/CT in a case of recurrent Glioblastoma

Arunachalam Raghupathi Vishnu et al. Indian J Nucl Med. 2025 Mar-Apr.

Abstract

Glioblastoma multiforme (GBM) is a high-grade brain tumor with a high recurrence rate. We present the case of a 57-year-old man with left frontal lobe GBM who was operated on and received radiation therapy in June 2023 and was referred for 68Ga-PSMA 11 PET/CT with a clinical suspicion of recurrence. The scan showed intense tracer uptake in the left frontal lobe lesion with severe edema, which was consistent with recurrence. Our case underscores the role of 68Ga PSMA 11 PET/CT imaging of suspected glioblastoma recurrence which is the initial step in GBM theranostics with PSMA.

Keywords: 68Ga-PSMA; PSMA recurrent glioblastoma; glioblastoma multiforme.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Maximum intensity projection image of the whole body ([a] green arrow) and brain (c) shows increased metabolism in the left frontal lobe. Positron emission tomography (PET) images [b – orange arrow] show hypermetabolism in the left frontal region. Computed tomography (CT) and 68Ga PSMA 11 PET/ CT scan ([d and e], axial CT and fused PET/CT; [f and g – green arrow], coronal CT and fused PET/CT) shows intense tracer uptake along the periphery of an irregular hypodense lesion in the left frontal lobe
See this image and copyright information in PMC

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