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Review
. 2025 Sep;43(9):383-393.
doi: 10.1177/15578550251363061. Epub 2025 Jul 30.

Photobiomodulation for Degenerative Diseases: An Overview and Perspectives

Affiliations
Review

Photobiomodulation for Degenerative Diseases: An Overview and Perspectives

Rosane F Z Lizarelli et al. Photobiomodul Photomed Laser Surg. 2025 Sep.

Abstract

Background: Photobiomodulation (PBM) is a well-established, noninvasive therapeutic modality supported by a robust scientific foundation and extensive case studies. Objectives: However, in recent years, researchers have reported that low-intensity light could also help slow down degenerative processes resulting from unbalanced or epigenetically exacerbated aging. Methods: We present data that support the use of PBM in addressing some of the primary degenerative diseases that significantly impact patients' quality of life. Results: Chronic diseases highlight the importance of emerging approaches utilizing low-power light sources, whether applied locally, systemically, or remotely. Conclusions: We conclude that PBM holds significant promise for patients suffering from chronic and debilitating conditions, offering potential therapeutic benefits. As the science of biophotonic continues to evolve, further advancements in light-based therapies are expected to enhance healing processes and improve the quality of life for patients worldwide. The growing body of evidence suggests that PBM is well-prepared to face the challenges imposed by degenerative diseases.

Keywords: aging; brain; degenerative joint disease; disorders; gut axis; integrative health; photobiomodulation; tinnitus.

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