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Case Reports
. 2025 Dec;54(12):2847-2851.
doi: 10.1007/s00256-025-04987-2. Epub 2025 Jul 30.

Spondylodiscitis revealing Whipple disease

Blandine Petain  1 , Lea Perrot  2 , Aurelie Daumas  3 , Jean-Christophe Lagier  4 , Thomas Le Corroller  5   6
Affiliations
Case Reports

Spondylodiscitis revealing Whipple disease

Blandine Petain et al. Skeletal Radiol. 2025 Dec.

Abstract

Whipple disease is a rare chronic infection caused by the Gram-positive intracellular bacterium Tropheryma whipplei. The classic clinical presentation includes digestive symptoms, weight loss, and polyarthralgia, with diagnosis requiring histological examination of duodenal biopsies and polymerase chain reaction (PCR). Localized forms of T. whipplei infection can significantly delay diagnosis. Spondylodiscitis is an extremely rare manifestation of Whipple disease with few cases reported in the literature. We present a case of subacute spondylodiscitis, assessed by MRI, in an 82-year-old patient with a previous history of seronegative rheumatoid arthritis unresponsive to treatment. Detection of the bacteria was confirmed through PCR on disco-vertebral biopsies while duodenal biopsies were normal. Symptoms rapidly improved with doxycycline and hydroxychloroquine treatment. This case highlights an atypical presentation of bone and joint manifestations in T. whipplei infection and the crucial role of specific PCR testing on biopsy material from affected tissues in the diagnostic process.

Keywords: Spondylodiscitis; T. whipple; Whipple.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: The patient was treated according to the highest standards of care available at the moment. This study was conducted in accordance with the Declaration of Helsinki of 1964 or any further amendment. Consent for to participate: Informed consent was obtained from the subject described in this report. Competing interests: The authors declare no competing interests.

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