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Review
. 2025:1467:281-283.
doi: 10.1007/978-3-031-72230-1_54.

Pathologic Myopia

Affiliations
Review

Pathologic Myopia

Sophie Z Gu et al. Adv Exp Med Biol. 2025.

Abstract

Pathologic myopia is defined by a refractive error exceeding -6.00 diopters with associated degenerative retinal changes due to axial elongation. Key risk factors include increased age, axial length, and high myopic spherical equivalent. Clinical presentation often begins in childhood and may include visual symptoms like scotomas and metamorphopsias. Fundus findings may include posterior staphyloma, tilted optic disc, and chorioretinal atrophy, among others. Advanced complications include lacquer cracks, Fuchs spots, and myopic traction maculopathy. Imaging modalities like OCT, FA, and OCT-A are crucial in monitoring disease progression and detecting complications. Early diagnosis and monitoring are essential to mitigate progressive vision loss.

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References

Further Readings

    1. Ip JM, Saw SM, Rose KA, et al. Role of near work in myopia: findings in a sample of Australian school children. Invest Ophthalmol Vis Sci 2008;49:2903-2910
    1. Lam JC, Li FF, Zhang X, Tang SM, et al. Two-year clinical trial of the low-concentration atropine for Myopia Progression (LAMP) study: phase 2 report. Ophthalmology 2020;127(7):910-19.
    1. Malagola R, Pecorella I, Teodori C, Santi G, Mannino G. Peripheral lacquer cracks as an early finding in pathological myopia. Arch Ophthalmol. 2006;124(12):1783–1784. doi: https://doi.org/10.1001/archopht.124.12.1783 - DOI
    1. Morgan I, Rose K. How genetic is school myopia? Prog Retinal Eye Res 2005;24:1-38.
    1. Ohno-Matsui K. What is the fundamental nature of pathologic myopia? Retina. 2017;37(6):1043–8.

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