Brain Organoids in the Study of Psychiatric Disorders

Yukyeong Lee^{1

2

3}, Paul K Reardon^{1

2

3

4}, Rakesh Karmacharya^{1

2

3

4}

Affiliations

¹ Center for Genomic Medicine, Massachusetts General Hospital, Boston.
² Department of Psychiatry, Harvard Medical School, Boston, Massachusetts.
³ Chemical Biology Program, Broad Institute, Cambridge, Massachusetts.
⁴ Schizophrenia and Bipolar Disorder Program, McLean Hospital, Belmont, Massachusetts.

Yukyeong Lee et al. JAMA Psychiatry. 2025.

. 2025 Jul 30.

doi: 10.1001/jamapsychiatry.2025.1869. Online ahead of print.

Yukyeong Lee^{1

2

3}, Paul K Reardon^{1

2

3

4}, Rakesh Karmacharya^{1

2

3

4}

¹ Center for Genomic Medicine, Massachusetts General Hospital, Boston.
² Department of Psychiatry, Harvard Medical School, Boston, Massachusetts.
³ Chemical Biology Program, Broad Institute, Cambridge, Massachusetts.
⁴ Schizophrenia and Bipolar Disorder Program, McLean Hospital, Belmont, Massachusetts.

No abstract available

Plain language summary

This article discusses the use of brain organoids in modeling the biological mechanisms of psychiatric disease.