Systemic sclerosis: one year in review 2025

Abstract

Systemic sclerosis is a rare and chronic connective tissue disease with a complex pathogenesis and highly heterogeneous clinical manifestations. Although significant progress has been made in understanding its underlying mechanisms, early diagnosis and therapeutic strategies, SSc remains a clinical challenge. Each year, several studies explore new insights into its pathogenesis, organ involvement, and treatment. This review provides an overview of the most relevant studies published in the literature in 2024.