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Review
. 2025 Jul:11:e2500200.
doi: 10.1200/GO-25-00200. Epub 2025 Jul 30.

First Decade of the National Cancer Institute's Affordable Cancer Technologies Program: Accelerating Translational Technology Research and Development for Cancer Globally

Paul C Pearlman  1 , Rao Divi  1 , Rebecca Huppi  1 , Elise Garton  1 , Srivatsan Kidambi  1 , Pushpa Tandon  1 , Miguel Ossandon  1 , Ophira Ginsburg  1 , Satish Gopal  1
Affiliations
Review

First Decade of the National Cancer Institute's Affordable Cancer Technologies Program: Accelerating Translational Technology Research and Development for Cancer Globally

Paul C Pearlman et al. JCO Glob Oncol. 2025 Jul.

Abstract

Since 2014, the National Cancer Institute Affordable Cancer Technologies (ACTs) program has supported a broad research portfolio focused on the development and validation of new technologies for global cancer control. ACTs projects are conducted by international teams composed of investigators from the United States and low- and middle-income countries, spurring important contextually relevant innovations. During its first decade, the ACTs program ushered in new technology platforms, led to commercialized products, and affected health policies and programs worldwide including in the United States. It has allowed a new generation of investigators working across disciplines and national borders to pursue novel technological solutions and leverage new analytic methods to advance human health. This commentary lays out the scope and accomplishments of the ACTs program to date while considering possible future research directions.

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Conflict of interest statement

The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated unless otherwise noted. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/go/authors/author-center.

Open Payments is a public database containing information reported by companies about payments made to US-licensed physicians (Open Payments).

No potential conflicts of interest were reported.

Figures

FIG 1
FIG 1
ACTs awards by cancer site and CSO code. Note that some awards may have multiple CSO codes and/or cancer sites. ACTs, Affordable Cancer Technologies; CSO, common scientific outline.
FIG 2
FIG 2
ACTs awards by RCDC codes. Note that some awards may have multiple RCDC codes. ACTs, Affordable Cancer Technologies; RCDC, Research, Condition, and Disease Categorization.
FIG 3
FIG 3
ACTs collaborator countries. Note that some projects have performance sites in several countries. ACTs, Affordable Cancer Technologies.
See this image and copyright information in PMC

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