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. 2025 Aug 5;86(5):400-403.
doi: 10.1016/j.jacc.2025.04.068.

Sex Differences in the Genetic Causes of Dilated Cardiomyopathy

Massimo Mangino  1 , Kathryn A McGurk  2 , Pantazis Theotokis  3 , Rachel J Buchan  4 , Clare R Stockwell  5 , Prisca K Thami  2 , Emma Jennings  5 , Elaine Wan  5 , Catherine Enright  5 , Ahmed Adlan  6 , Tamim Akbari  4 , John Baksi  7 , Paul J R Barton  8 , Colin Berry  9 , Gerry Carr-White  10 , Amedeo Chiribiri  11 , Rob Cooper  12 , Abhishek Dattani  13 , Andrew S Flett  14 , Roy S Gardner  9 , John P Greenwood  15 , Brian P Halliday  4 , Daniel J Hammersley  16 , David C Hutchings  6 , Masliza Mahmod  17 , Benjamin Marrow  13 , Gerry P McCann  13 , Manish Motwani  18 , Stefan Neubauer  19 , Declan P O' Regan  20 , Stephen P Page  19 , Antonis Pantazis  7 , Charles Peebles  14 , Betty Raman  17 , Peter P Swoboda  21 , Amanda Varnava  22 , Luigi Venetucci  6 , Hugh Watkins  17 , David Wright  23 , Sanjay K Prasad  4 , Stuart A Cook  3 , James S Ware  24 , Upasana Paz Tayal  25 ; GO-DCM Investigators
Collaborators, Affiliations

Sex Differences in the Genetic Causes of Dilated Cardiomyopathy

Massimo Mangino et al. J Am Coll Cardiol. .
No abstract available

Keywords: DCM; desmoplakin; sex differences.

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Conflict of interest statement

Funding Support and Author Disclosures This work is supported by the Medical Research Council (MR/W023830/1; MC-A658-5TY00, MC_UP_1605/13), the British Heart Foundation [SP/17/11/32885; RE/18/4/34215; BBC/F/21/220106, FS/IPBSRF/22/27059, RG/19/6/34387, RE/24/130023, CH/P/23/80008; FS/ICRF/21/26019], Sir Jules Thorn Charitable Trust (21JTA), NHLI Foundation Royston Centre for Cardiomyopathy Research, Rosetrees Trust and the NIHR Imperial College Biomedical Research Centre. Drs Neubauer and Raman have received support from the Oxford NIHR Biomedical Research Centre. The funders did not have a role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication. Dr McGurk has served as a consultant for Checkpoint Capital LP. Dr Cooper has served as a consultant for Bristol Myers Squibb; and has received speaker fees for Pfizer, Alnylam. Dr Gardner has served as a consultant for Abbott, Anacardio, AstraZeneca, Boehringer Ingelheim, Boston Scientific, Novartis, Pfizer, Pharmacosmos, and Roche Diagnostics; and has received research support from Abbott, Boston Scientific, and Roche Diagnostics. Dr Halliday has served as a consultant for AstraZeneca and Zoll. Dr O’Regan has served as a consultant for Bayer AG and Bristol Myers Squibb; and has received grant support from Bayer AG and Calico Labs. Dr Raman is funded by a Wellcome Career Development Award fellowship (302210/Z/23/Z). Dr Wright has consulted for Boston Scientific, Medtronic and iRhythm. Dr Ware has served as a consultant for MyoKardia, Inc, Pfizer, Foresite Labs, Health Lumen, and Tenaya Therapeutics; and has received research support from Bristol Myers Squibb. Dr Tayal has received fees for educational content from Chiesi Medical; is a committee member of the British Cardiovascular Society and Royal Society; and is a consultant (Research Editor) for the British Medical Journal. None of these activities are directly related to the work presented here. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

References

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