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. 2025 Apr 29:39:61.
doi: 10.47176/mjiri.39.61. eCollection 2025.

Factors Affecting IVF Success after Laparoscopic Surgery in Women with Endometriosis

Abolfazl Mehdizadehkashi  1 , Shahla Chaichian  2 , Roya Derakhshan  1 , Farahnaz Farzaneh  3 , Azam Govahi  1 , Azar Mohammadzadeh  2 , Banafsheh Nikfar  2 , Yasaman Kabir Anaraki  3
Affiliations

Factors Affecting IVF Success after Laparoscopic Surgery in Women with Endometriosis

Abolfazl Mehdizadehkashi et al. Med J Islam Repub Iran. .

Abstract

Background: Considering low-quality evidence regarding the impact of laparoscopic surgery on in vitro fertilization (IVF) success rates in women with endometriosis, our research aimed to evaluate IVF success rates and their influential factors in women with endometriosis-related infertility who underwent laparoscopic surgery.

Methods: In a retrospective cohort study, we included women aged 15 to 40 years diagnosed with endometriosis-related infertility who underwent laparoscopic surgery in a university hospital. Women with severe male factor infertility, adenomyosis, uterine myomas, premature ovarian insufficiency, incomplete information, or inaccessible data from infertility centers were excluded. Data were collected from the Endometriosis Data Registry approved by the Iran University of Medical Sciences under code number 1400-2-65-21233, including age, body mass index, infertility duration, endometriosis severity, and Anti-Müllerian hormone levels before IVF. IVF success was considered by an embryonic heartbeat identification during an ultrasound exam, that is, a clinical pregnancy. Independent sample t test, Mann-Whitney, and chi-square tests were applied for single-variable analysis, and logistic regression was used for multivariable analysis.

Results: Of 55 eligible patients, IVF was successful in 23 (41.81%). The mean age of participants was 34.98 years, with a standard deviation of 5.93 years. Endometriomas were observed in 42 (76%) of the participants; unilateral endometriomas were more common than bilateral (25 [45.5%] vs 17 [30.9%]). No significant differences were identified between the IVF-positive and IVF-negative groups regarding clinical and demographic characteristics.

Conclusion: Laparoscopic surgery in women with deep infiltrating endometriosis enhances IVF success and increases pregnancy rate.

Keywords: Assisted Reproductive Technique; Endometriosis; In Vitro Fertilization; Infertility; Laparoscopy.

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Conflict of interest statement

The authors declare that they have no competing interests.

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