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Review
. 2025 Jul 25:18:9871-9878.
doi: 10.2147/JIR.S527506. eCollection 2025.

Exploring the Importance of ZBP1 in Sepsis: A Mini Review on It's Mechanisms and Progress

Jie Liu #  1   2 , Jian Feng #  3 , Jian Hu  3 , Juan Chen  3 , Fu-Xiang Li  2   3 , Ning Lin  1   2
Affiliations
Review

Exploring the Importance of ZBP1 in Sepsis: A Mini Review on It's Mechanisms and Progress

Jie Liu et al. J Inflamm Res. .

Abstract

Sepsis is defined as a severe systemic inflammation, often triggered by an infection, resulting in organ dysfunction and mortality. In recent years, ZBP1 (Z-DNA binding protein 1) has garnered significant attention as a critical immune regulatory factor in the pathogenesis of sepsis. This article aims to comprehensively explore the mechanisms by which ZBP1 operates in sepsis and summarize the relevant research progress. This study will seek to highlight the potential of ZBP1 as a therapeutic target and biomarker in the context of sepsis through an in-depth analysis of its functions in cellular signaling, inflammatory response, and immune response. This review seeks to provide new insights for the clinical management of sepsis.

Keywords: ZBP1; immune regulation; inflammatory response; research progress; sepsis.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Pathogenesis of sepsis and the role of ZBP1 in sepsis.
See this image and copyright information in PMC

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