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Review
. 2025 Jul 16:13:1586898.
doi: 10.3389/fbioe.2025.1586898. eCollection 2025.

Research progress of implantable materials in antibacterial treatment of bone infection

Binqing Xiang  1 , Jingui Jiang  2 , Heng Wang  3 , Lei Song  4
Affiliations
Review

Research progress of implantable materials in antibacterial treatment of bone infection

Binqing Xiang et al. Front Bioeng Biotechnol. .

Abstract

Bone infection is an infectious disease characterized by the accumulation of various pathogens in bone tissue, often causing significant suffering to patients. Current therapeutic approaches for bone infections predominantly rely on the postoperative application of implantable antibacterial materials, highlighting their essential role in clinical treatment. In this review, we systematically analyze research progress in antibacterial implant materials for Bone infection from 2019 to 2025. Materials are classified into four categories based on matrix composition: metal-based composite implants, bioceramic-based composite implants, polymer-based composite implants, and other composite implant materials, with dedicated focus on the limitations of each material type. The deterioration effects of these materials are also thoroughly analyzed. Finally, we present our own insights regarding future development directions of antibacterial implant materials. This review aims to provide practical references and research perspectives for advancing antibacterial implant material development.

Keywords: antibacterial treatment; bone infection; composite materials; implantable materials; material matrix.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Pathogenesis of S. aureus infection bones, self-drawn.
FIGURE 2
FIGURE 2
Pathogenesis of S. aureus infection bones, self-drawn.
FIGURE 3
FIGURE 3
Illustrates the development of bioceramic-based materials, reproduced from (Nguyen et al., 2024) with permission.
See this image and copyright information in PMC

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