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. 2025 Aug 15;39(15):e70875.
doi: 10.1096/fj.202500469RR.

Nicotinamide Mononucleotide Alleviates Aging Defects in Hutchinson-Gilford Progeria Syndrome

Yuyan Xu  1 , Mengchen Wu  1 , Yuhang Fan  2 , Jia Zhang  1 , Dixuan Xue  1 , Ming Zhang  1 , Rouyi Shao  1 , Limeng Cai  3 , Xufeng Liao  1 , Ling Zhang  2 , Jin Zhang  1   4
Affiliations

Nicotinamide Mononucleotide Alleviates Aging Defects in Hutchinson-Gilford Progeria Syndrome

Yuyan Xu et al. FASEB J. .

Abstract

Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by mutations in the LMNA gene, leading to progerin accumulation and accelerated aging. Current therapeutic interventions remain limited. Here, we demonstrate that supplementation with nicotinamide mononucleotide (NMN) markedly ameliorates HGPS-associated phenotypes at both the cellular and organismal levels. In patient-derived induced pluripotent stem cell-mesenchymal stem cells, NMN supplementation enhanced NAD+ biosynthesis, restored mitochondrial function, reduced DNA damage, and mitigated oxidative stress. Furthermore, 4 months of NMN administration in G608G transgenic mouse models resulted in significant improvements in gonadal function, cardiovascular parameters, skin pathology, and lifespan extension. These comprehensive findings establish NMN supplementation as a promising therapeutic approach for HGPS and potentially other age-related disorders.

Keywords: Hutchinson–Gilford progeria syndrome; aging; gonadal function; mitochondria; nicotinamide mononucleotide.

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References

    1. C. López‐Otín, M. Blasco, L. Partridge, M. Serrano, and G. Kroemer, “Hallmarks of Aging: An Expanding Universe,” Cell 186, no. 2 (2023): 243–278.
    1. W. Zhang, J. Qu, G. H. Liu, and J. C. I. Belmonte, “The Ageing Epigenome and Its Rejuvenation,” Nature Reviews. Molecular Cell Biology 21, no. 3 (2020): 137–150.
    1. M. S. Ahmed, S. Ikram, N. Bibi, and A. Mir, “Hutchinson‐Gilford Progeria Syndrome: A Premature Aging Disease,” Molecular Neurobiology 55, no. 5 (2018): 4417–4427.
    1. M. Eriksson, W. T. Brown, L. B. Gordon, et al., “Recurrent de Novo Point Mutations in Lamin A Cause Hutchinson‐Gilford Progeria Syndrome,” Nature 423, no. 6937 (2003): 293–298.
    1. C. Lopez‐Otin, M. A. Blasco, L. Partridge, M. Serrano, and G. Kroemer, “The Hallmarks of Aging,” Cell 153, no. 6 (2013): 1194–1217.

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