Targeting Platelet MCU: A Promising Therapeutic Strategy?

doi:10.1161/CIRCRESAHA.125.326943

Editorial

. 2025 Aug;137(4):493-495.

doi: 10.1161/CIRCRESAHA.125.326943. Epub 2025 Jul 31.

Targeting Platelet MCU: A Promising Therapeutic Strategy?

Kanika Jain^{1

2}, John Hwa^{1

2}

Affiliations

¹ Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (K.J., J.H.).
² Yale Cooperative Center of Excellence in Hematology, Department of Pathology, Yale School of Medicine, New Haven, CT (K.J., J.H.).

PMID: 40743303
PMCID: PMC12321218 (available on 2026-07-31)
DOI: 10.1161/CIRCRESAHA.125.326943

Editorial

Targeting Platelet MCU: A Promising Therapeutic Strategy?

Kanika Jain et al. Circ Res. 2025 Aug.

. 2025 Aug;137(4):493-495.

doi: 10.1161/CIRCRESAHA.125.326943. Epub 2025 Jul 31.

Authors

Kanika Jain^{1

2}, John Hwa^{1

2}

Affiliations

¹ Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (K.J., J.H.).
² Yale Cooperative Center of Excellence in Hematology, Department of Pathology, Yale School of Medicine, New Haven, CT (K.J., J.H.).

PMID: 40743303
PMCID: PMC12321218 (available on 2026-07-31)
DOI: 10.1161/CIRCRESAHA.125.326943

No abstract available

Keywords: Editorials; blood platelets; hemostasis; mitochondria; platelet aggregation inhibitors; signal transduction; thrombosis.

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Conflict of interest statement

None.

Comment on

Mitochondrial Calcium Uniporter Regulates ITAM-Dependent Platelet Activation.
Ajanel A, Andrianova I, Kowalczyk M, Menéndez-Pérez J, Bhatt SR, Portier I, Boone TC, Ballard-Kordeliski A, Kosaka Y, Chaudhuri D, Paul DS, Bergmeier W, Denorme F, Campbell RA. Ajanel A, et al. Circ Res. 2025 Aug;137(4):474-492. doi: 10.1161/CIRCRESAHA.125.326443. Epub 2025 Jul 1. Circ Res. 2025. PMID: 40590119

References

1. Jain K, Tyagi T, Gu SX, Faustino EVS, Hwa J. Demographic diversity in platelet function and response to antiplatelet therapy. Trends Pharmacol Sci. 2025;46:78–93. doi: 10.1016/j.tips.2024.11.005 - DOI - PMC - PubMed
1. Tyagi T, Jain K, Gu SX, Qiu M, Gu VW, Melchinger H, Rinder H, Martin KA, Gardiner EE, Lee AI, et al. A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences. Nature Cardiovascular Research. 2022;1:223–237. doi: 10.1038/s44161-022-00021-z - DOI - PMC - PubMed
1. Shehwar D, Barki S, Aliotta A, Calderara DB, Veuthey L, Portela CP, Alberio L, Alam MR. Platelets and mitochondria: the calcium connection. Mol Biol Rep. 2025;52:276. doi: 10.1007/s11033-025-10389-3 - DOI - PubMed
1. Melchinger H, Jain K, Tyagi T, Hwa J. Role of Platelet Mitochondria: Life in a Nucleus-Free Zone. Front Cardiovasc Med. 2019;6:153. doi: 10.3389/fcvm.2019.00153 - DOI - PMC - PubMed
1. Ajanel A, Campbell RA, Denorme F. Platelet mitochondria: the mighty few. Curr Opin Hematol. 2023;30:167–174. doi: 10.1097/MOH.0000000000000772 - DOI - PMC - PubMed

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[1] Jain K, Tyagi T, Gu SX, Faustino EVS, Hwa J. Demographic diversity in platelet function and response to antiplatelet therapy. Trends Pharmacol Sci. 2025;46:78–93. doi: 10.1016/j.tips.2024.11.005 - DOI - PMC - PubMed

[2] Jain K, Tyagi T, Gu SX, Faustino EVS, Hwa J. Demographic diversity in platelet function and response to antiplatelet therapy. Trends Pharmacol Sci. 2025;46:78–93. doi: 10.1016/j.tips.2024.11.005 - DOI - PMC - PubMed

[3] Tyagi T, Jain K, Gu SX, Qiu M, Gu VW, Melchinger H, Rinder H, Martin KA, Gardiner EE, Lee AI, et al. A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences. Nature Cardiovascular Research. 2022;1:223–237. doi: 10.1038/s44161-022-00021-z - DOI - PMC - PubMed

[4] Tyagi T, Jain K, Gu SX, Qiu M, Gu VW, Melchinger H, Rinder H, Martin KA, Gardiner EE, Lee AI, et al. A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences. Nature Cardiovascular Research. 2022;1:223–237. doi: 10.1038/s44161-022-00021-z - DOI - PMC - PubMed

[5] Shehwar D, Barki S, Aliotta A, Calderara DB, Veuthey L, Portela CP, Alberio L, Alam MR. Platelets and mitochondria: the calcium connection. Mol Biol Rep. 2025;52:276. doi: 10.1007/s11033-025-10389-3 - DOI - PubMed

[6] Shehwar D, Barki S, Aliotta A, Calderara DB, Veuthey L, Portela CP, Alberio L, Alam MR. Platelets and mitochondria: the calcium connection. Mol Biol Rep. 2025;52:276. doi: 10.1007/s11033-025-10389-3 - DOI - PubMed

[7] Melchinger H, Jain K, Tyagi T, Hwa J. Role of Platelet Mitochondria: Life in a Nucleus-Free Zone. Front Cardiovasc Med. 2019;6:153. doi: 10.3389/fcvm.2019.00153 - DOI - PMC - PubMed

[8] Melchinger H, Jain K, Tyagi T, Hwa J. Role of Platelet Mitochondria: Life in a Nucleus-Free Zone. Front Cardiovasc Med. 2019;6:153. doi: 10.3389/fcvm.2019.00153 - DOI - PMC - PubMed

[9] Ajanel A, Campbell RA, Denorme F. Platelet mitochondria: the mighty few. Curr Opin Hematol. 2023;30:167–174. doi: 10.1097/MOH.0000000000000772 - DOI - PMC - PubMed

[10] Ajanel A, Campbell RA, Denorme F. Platelet mitochondria: the mighty few. Curr Opin Hematol. 2023;30:167–174. doi: 10.1097/MOH.0000000000000772 - DOI - PMC - PubMed

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Targeting Platelet MCU: A Promising Therapeutic Strategy?

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Targeting Platelet MCU: A Promising Therapeutic Strategy?

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