Integrin'g Endocytosis and Vascular Calcification in Chronic Kidney Disease

Rolando A Cuevas¹, Cynthia St Hilaire^{1

2

3

4}

Affiliations

¹ Pittsburgh Heart, Lung, and Blood, Vascular Medicine Institute (R.A.C., C.S.H.), University of Pittsburgh, PA.
² Division of Cardiology, Department of Medicine (C.S.H.), University of Pittsburgh, PA.
³ Department of Cardiothoracic Surgery (C.S.H.), University of Pittsburgh, PA.
⁴ Department of Bioengineering (C.S.H.), University of Pittsburgh, PA.

Editorial

Rolando A Cuevas et al. Circ Res. 2025 Aug.

. 2025 Aug;137(4):569-571.

doi: 10.1161/CIRCRESAHA.125.326945. Epub 2025 Jul 31.

Rolando A Cuevas¹, Cynthia St Hilaire^{1

2

3

4}

¹ Pittsburgh Heart, Lung, and Blood, Vascular Medicine Institute (R.A.C., C.S.H.), University of Pittsburgh, PA.
² Division of Cardiology, Department of Medicine (C.S.H.), University of Pittsburgh, PA.
³ Department of Cardiothoracic Surgery (C.S.H.), University of Pittsburgh, PA.
⁴ Department of Bioengineering (C.S.H.), University of Pittsburgh, PA.

No abstract available

Keywords: Editorials; calcium; endocytosis; integrins; kidney.

Conflict of interest statement

None.

TRIM16 Mediates K63-Linked Ubiquitination of DAB2 to Facilitate Vascular Calcification.
Lan Z, Liang Q, Li L, Liu F, Chen A, Ye Y, Feng L, Zhang Z, Zhang X, Ou JS, Lu L, Yan J. Lan Z, et al. Circ Res. 2025 Aug;137(4):551-568. doi: 10.1161/CIRCRESAHA.125.326520. Epub 2025 Jun 27. Circ Res. 2025. PMID: 40575853

1. Kutikhin AG, Feenstra L, Kostyunin AE, Yuzhalin AE, Hillebrands JL, Krenning G. Calciprotein Particles: Balancing Mineral Homeostasis and Vascular Pathology. Arterioscler Thromb Vasc Biol. 2021;41:1607–1624. doi: 10.1161/ATVBAHA.120.315697 - DOI - PMC - PubMed
1. Lacerda-Abreu MA, Meyer-Fernandes JR. Extracellular Inorganic Phosphate-Induced Release of Reactive Oxygen Species: Roles in Physiological Processes and Disease Development. Int J Mol Sci. 2021;22. doi: 10.3390/ijms22157768 - DOI - PMC - PubMed
1. Zoccali C, Mallamaci F. Innate Immunity System in Patients With Cardiovascular and Kidney Disease. Circ Res. 2023;132:915–932. doi: 10.1161/CIRCRESAHA.122.321749 - DOI - PubMed
1. Glorieux G, Nigam SK, Vanholder R, Verbeke F. Role of the Microbiome in Gut-Heart-Kidney Cross Talk. Circ Res. 2023;132:1064–1083. doi: 10.1161/CIRCRESAHA.123.321763 - DOI - PubMed
1. Pagan J, Seto T, Pagano M, Cittadini A. Role of the ubiquitin proteasome system in the heart. Circ Res. 2013;112:1046–1058. doi: 10.1161/CIRCRESAHA.112.300521 - DOI - PubMed