Lactylation: A New Metabolic Signature of Sepsis-Related Cardiac Dysfunction

Nahum F Arefeayne^{1

2}, Jennifer Q Kwong^{2

3}

Affiliations

¹ Graduate Program in Biochemistry, Cell and Developmental Biology, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA (N.F.A.).
² Division of Pediatric Cardiology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, GA (N.F.A., J.Q.K.).
³ Department of Cell Biology, Emory University School of Medicine, Atlanta, GA (J.Q.K.).

Editorial

Nahum F Arefeayne et al. Circ Res. 2025 Aug.

. 2025 Aug;137(4):516-518.

doi: 10.1161/CIRCRESAHA.125.326834. Epub 2025 Jul 31.

Nahum F Arefeayne^{1

2}, Jennifer Q Kwong^{2

3}

¹ Graduate Program in Biochemistry, Cell and Developmental Biology, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA (N.F.A.).
² Division of Pediatric Cardiology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, GA (N.F.A., J.Q.K.).
³ Department of Cell Biology, Emory University School of Medicine, Atlanta, GA (J.Q.K.).

No abstract available

Keywords: Editorials; cardiomyopathies; heart diseases; mitochondria; morbidity; sepsis.

Conflict of interest statement

None.

Lactylation of HADHA Promotes Sepsis-Induced Myocardial Depression.
Zhang TN, Huang XM, Li L, Li Y, Liu YP, Shi XL, Wu QJ, Wen R, Yang YH, Zhang T, Gong TT, Liu FH, Liu CF, Ning W, Yang N. Zhang TN, et al. Circ Res. 2025 Aug;137(4):e65-e87. doi: 10.1161/CIRCRESAHA.124.325708. Epub 2025 Jun 27. Circ Res. 2025. PMID: 40575877

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