Dot1L-H3K79me2-Tbx6 Axis: A Novel Therapeutic Target for Preventing Cardiac Failure

Tomás M Peralta^{1

2

3}, Laura C Zelarayán^{1

2

3

4}

Affiliations

¹ Institute of Pharmacology and Toxicology, University Medical Center Göttingen, Germany (T.M.P., L.C.Z.).
² German Centre for Cardiovascular Research (DZHK), partner site Lower Saxony, Germany (T.M.P., L.C.Z.).
³ Cardio-Pulmonary Institute (CPI), Giessen, Germany (T.M.P., L.C.Z.).
⁴ Medical Clinic I, Department of Cardiology and Angiology, Justus Liebig University, Giessen, Germany (L.C.Z.).

Editorial

Tomás M Peralta et al. Circ Res. 2025 Aug.

. 2025 Aug;137(4):513-515.

doi: 10.1161/CIRCRESAHA.125.326946. Epub 2025 Jul 31.

Tomás M Peralta^{1

2

3}, Laura C Zelarayán^{1

2

3

4}

¹ Institute of Pharmacology and Toxicology, University Medical Center Göttingen, Germany (T.M.P., L.C.Z.).
² German Centre for Cardiovascular Research (DZHK), partner site Lower Saxony, Germany (T.M.P., L.C.Z.).
³ Cardio-Pulmonary Institute (CPI), Giessen, Germany (T.M.P., L.C.Z.).
⁴ Medical Clinic I, Department of Cardiology and Angiology, Justus Liebig University, Giessen, Germany (L.C.Z.).

No abstract available

Keywords: Editorials; epigenomics; heart failure; histones; hypertrophy.

Conflict of interest statement

None.

Dot1L Promotes Stress-Induced Cardiac Hypertrophy in Mice via Tbx6.
Liu J, Jin Y, Zuo S, Mu C, Wang B, Huang D, Liu Q, Zhang K, Song J, Xuan C, Zhang J, Yu Y. Liu J, et al. Circ Res. 2025 Aug;137(4):496-512. doi: 10.1161/CIRCRESAHA.124.324940. Epub 2025 Jun 30. Circ Res. 2025. PMID: 40583756