Translational traffic jam in aging brains

Olivier Dionne¹, Benoit Laurent^{1

2}

Affiliations

¹ Department of Biochemistry and Functional Genomics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
² Research Center on Aging, Centre Intégré Universitaire de Santé et Services Sociaux de l'Estrie-Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.

Comment

Olivier Dionne et al. Science. 2025.

. 2025 Jul 31;389(6759):457-458.

doi: 10.1126/science.adz4995. Epub 2025 Jul 31.

Olivier Dionne¹, Benoit Laurent^{1

2}

¹ Department of Biochemistry and Functional Genomics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
² Research Center on Aging, Centre Intégré Universitaire de Santé et Services Sociaux de l'Estrie-Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.

Abstract

Ribosome stalling drives aging in the killifish brain.

Altered translation elongation contributes to key hallmarks of aging in the killifish brain.
Di Fraia D, Marino A, Lee JH, Kelmer Sacramento E, Baumgart M, Bagnoli S, Balla T, Schalk F, Kamrad S, Guan R, Caterino C, Giannuzzi C, Tomaz da Silva P, Sahu AK, Gut H, Siano G, Tiessen M, Terzibasi-Tozzini E, Fornasiero EF, Gagneur J, Englert C, Patil KR, Correia-Melo C, Nedialkova DD, Frydman J, Cellerino A, Ori A. Di Fraia D, et al. Science. 2025 Jul 31;389(6759):eadk3079. doi: 10.1126/science.adk3079. Epub 2025 Jul 31. Science. 2025. PMID: 40743332