Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2026 Jan:291:10-13.
doi: 10.1016/j.ahj.2025.07.070. Epub 2025 Jul 29.

The low-risk TAVR trials-A critical appraisal of the current landscape

Troels Højsgaard Jørgensen  1 , Hans Gustav Hørsted Thyregod  1 , Stefan Blankenberg  2 , Martin Leon  3 , Lars Sondergaard  4 , Bernard Prendergast  5 , Ole De Backer  6
Affiliations
Free article
Review

The low-risk TAVR trials-A critical appraisal of the current landscape

Troels Højsgaard Jørgensen et al. Am Heart J. 2026 Jan.
Free article

Abstract

The low-risk TAVR vs SAVR RCTs - PARTNER-3, Evolut Low-Risk, DEDICATE, and NOTION-2 - demonstrate that TAVR is at least as effective as SAVR in terms of early mortality and disabling stroke, although outcomes varied across studies. The excellent outcomes observed in the PARTNER-3 trial reflect the highly selected patient population, while the NOTION-2 trial highlights the challenges posed by anatomical variations, such as bicuspid aortic valves (AV). These findings highlight the importance of a personalized approach guided by a multidisciplinary Heart Team, taking into account both clinical and anatomical aspects when choosing between TAVR and SAVR. Trial registration number: ClinicalTrials.gov NCT02825134.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest Predergast, B is member of the Anteris Technologies Advisory Board, Medtronic Trial Steering Committee and Valvosoft Data Safety Monitoring Committee. Leon, M has received grants from Edwards Lifesciences, Abbott Vascular and Medtronic, consultant fees from Foldax and Anteris Technologies, is a member of the Medtronic Data Safety Monitoring Board, has a leadership role in the Heart Valve Collaboratory and stock equity in Pi-Cardia; Søndergaard, L. is an employee at Abbott. De Baclker, O. received institutional research grants and consulting fees from Abbott, Boston Scientific, and Medtronic.

MeSH terms

Associated data