Extraintestinal Symptoms in Irritable Bowel Syndrome Are Associated With Stress Reactivity and the Gut Microbiome in a Sex-dependent Manner

Jonathan P Jacobs¹, Jennifer S Labus², Tien S Dong², Andrea S Shin²; UCLA SCORE Group in IBS and Sex Differences; Emeran A Mayer², Lin Chang⁴

Collaborators, Affiliations

Collaborators

UCLA SCORE Group in IBS and Sex Differences:
Arpana Church³, Swapna Mahurkar-Joshi³, Elaine Hsiao³, Bruce D Naliboff³, Cathy Liu³

Affiliations

¹ Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California; Goodman-Luskin Microbiome Center, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California; G. Oppenheimer Center for Neurobiology of Stress and Resilience, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California; Division of Gastroenterology, Hepatology, and Parenteral Nutrition, VA Greater Los Angeles Healthcare System, Los Angeles, California. Electronic address: jjacobs@mednet.ucla.edu.
² Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California; Goodman-Luskin Microbiome Center, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California; G. Oppenheimer Center for Neurobiology of Stress and Resilience, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
³ Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California; Goodman-Luskin Microbiome Center, David Geffen School of Medicine at UCLA, Los Angeles, California; G. Oppenheimer Center for Neurobiology of Stress and Resilience, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
⁴ Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California; Goodman-Luskin Microbiome Center, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California; G. Oppenheimer Center for Neurobiology of Stress and Resilience, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California. Electronic address: linchang@mednet.ucla.edu.

PMID: 40744347
DOI: 10.1016/j.cgh.2025.07.026

Free article

Extraintestinal Symptoms in Irritable Bowel Syndrome Are Associated With Stress Reactivity and the Gut Microbiome in a Sex-dependent Manner

Jonathan P Jacobs et al. Clin Gastroenterol Hepatol. 2025.

Free article

. 2025 Jul 29:S1542-3565(25)00640-8.

doi: 10.1016/j.cgh.2025.07.026. Online ahead of print.

Authors

Jonathan P Jacobs¹, Jennifer S Labus², Tien S Dong², Andrea S Shin²; UCLA SCORE Group in IBS and Sex Differences; Emeran A Mayer², Lin Chang⁴

Collaborators

UCLA SCORE Group in IBS and Sex Differences:
Arpana Church³, Swapna Mahurkar-Joshi³, Elaine Hsiao³, Bruce D Naliboff³, Cathy Liu³

Affiliations

¹ Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California; Goodman-Luskin Microbiome Center, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California; G. Oppenheimer Center for Neurobiology of Stress and Resilience, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California; Division of Gastroenterology, Hepatology, and Parenteral Nutrition, VA Greater Los Angeles Healthcare System, Los Angeles, California. Electronic address: jjacobs@mednet.ucla.edu.
² Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California; Goodman-Luskin Microbiome Center, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California; G. Oppenheimer Center for Neurobiology of Stress and Resilience, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
³ Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California; Goodman-Luskin Microbiome Center, David Geffen School of Medicine at UCLA, Los Angeles, California; G. Oppenheimer Center for Neurobiology of Stress and Resilience, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
⁴ Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California; Goodman-Luskin Microbiome Center, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California; G. Oppenheimer Center for Neurobiology of Stress and Resilience, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California. Electronic address: linchang@mednet.ucla.edu.

PMID: 40744347
DOI: 10.1016/j.cgh.2025.07.026

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Extraintestinal Symptoms in Irritable Bowel Syndrome Are Associated With Stress Reactivity and the Gut Microbiome in a Sex-dependent Manner

Collaborators

Affiliations

Extraintestinal Symptoms in Irritable Bowel Syndrome Are Associated With Stress Reactivity and the Gut Microbiome in a Sex-dependent Manner

Authors

Collaborators

Affiliations

LinkOut - more resources

Full Text Sources