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. 2025 Jul 30:S1471-4914(25)00169-8.
doi: 10.1016/j.molmed.2025.07.003. Online ahead of print.

Autoantibodies as drivers of neuropathic pain

Adham Farah  1 , Omar Daifallah  2 , Evanka Singh  1 , John M Dawes  3
Affiliations

Autoantibodies as drivers of neuropathic pain

Adham Farah et al. Trends Mol Med. .

Abstract

Emerging evidence, supported by clinical responses to immunotherapy and the recapitulation of sensory symptoms in passive transfer models, shows that autoantibodies (AAbs) may drive neuropathic pain. These findings highlight the importance of immune profiling to enhance diagnosis and treatment, and provide molecular insights into broader pain mechanisms in clinical contexts.

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Conflict of interest statement

Declaration of interests The authors have no interests to declare.

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