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Review
. 2025:1482:49-60.
doi: 10.1007/978-3-031-97035-1_3.

Nonautonomous Regulation of Tumor Growth

Priya Kumar  1   2 , Hyun Soo Ko  1   2 , Louise Y Cheng  3   4   5
Affiliations
Review

Nonautonomous Regulation of Tumor Growth

Priya Kumar et al. Adv Exp Med Biol. 2025.

Abstract

Upon deregulation of growth control, cells and organs lose their ability to maintain size and function. In addition to autonomous mechanisms, nonautonomous regulators play key roles in controlling tumor growth. In this chapter, we will summarize the work, which identified novel communication factors between the tumor and its microenvironment, and the downstream genetic pathways and outputs of these cell-autonomous and nonautonomous interactions during tumor growth.

Keywords: Cancer cachexia; Interorgan crosstalk; Nutrients; Tumor.

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References

    1. Alpar L, Bergantiños C, Johnston LA (2018) Spatially restricted regulation of spätzle/toll signaling during cell competition. Dev Cell 46(6):706–719.e5. https://doi.org/10.1016/j.devcel.2018.08.001 - DOI
    1. Jeannine Bachmann et al (2009) Pancreatic cancer related cachexia: influence on metabolism and correlation to weight loss and pulmonary function – PubMed’. Accessed: Jun 11, 2024. [Online]. Available: https://pubmed.ncbi.nlm.nih.gov/19635171/
    1. Baker NE (2020) Emerging mechanisms of cell competition. Nat Rev Genet 21(11):683–697. https://doi.org/10.1038/s41576-020-0262-8 - DOI
    1. Bakopoulos D et al (2023) Convergent insulin and TGF-β signalling drives cancer cachexia by promoting aberrant fat body ECM accumulation in a drosophila tumour model. EMBO Rep 24(12):e57695. https://doi.org/10.15252/embr.202357695 - DOI
    1. Ballesteros-Arias L, Saavedra V, Morata G (2013) Cell competition may function either as tumour-suppressing or as tumour-stimulating factor in drosophila. Oncogene 33:4377. https://doi.org/10.1038/onc.2013.407 - DOI

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