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. 1985 Nov;20(5):475-8.
doi: 10.1111/j.1365-2125.1985.tb05100.x.

Evidence against an acetylcholine releasing action of cisapride in the human colon

D E Burleigh, S J Trout

Evidence against an acetylcholine releasing action of cisapride in the human colon

D E Burleigh et al. Br J Clin Pharmacol. 1985 Nov.

Abstract

The effect of cisapride (R51619) on intrinsic cholinergic nerve activity of human sigmoid taenia coli muscle strips (taenia) was assessed using radiolabelling techniques. Taeniae previously incubated with [3H]-choline were exposed to cisapride (0.41 and 4.1 microM), placebo solution and electrical field stimulation (EFS; 10 Hz, 1 ms, 200 mA for 480 pulses). Cisapride did not affect unstimulated (basal) release of radioactive material nor the release evoked by EFS. It was concluded that cisapride did not demonstrate a cholinomimetic effect in human sigmoid taenia coli muscle strips.

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References

    1. Can J Physiol Pharmacol. 1976 Feb;54(1):12-22 - PubMed
    1. Acta Physiol Scand. 1977 Nov;101(3):302-17 - PubMed
    1. Br J Pharmacol. 1978 Dec;64(4):565-80 - PubMed
    1. Br J Pharmacol Chemother. 1964 Aug;23:164-75 - PubMed
    1. Scand J Gastroenterol Suppl. 1984;92:8-12 - PubMed

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