Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985 Nov;20(5):475-8.
doi: 10.1111/j.1365-2125.1985.tb05100.x.

Evidence against an acetylcholine releasing action of cisapride in the human colon

D E Burleigh, S J Trout

Evidence against an acetylcholine releasing action of cisapride in the human colon

D E Burleigh et al. Br J Clin Pharmacol. 1985 Nov.

Abstract

The effect of cisapride (R51619) on intrinsic cholinergic nerve activity of human sigmoid taenia coli muscle strips (taenia) was assessed using radiolabelling techniques. Taeniae previously incubated with [3H]-choline were exposed to cisapride (0.41 and 4.1 microM), placebo solution and electrical field stimulation (EFS; 10 Hz, 1 ms, 200 mA for 480 pulses). Cisapride did not affect unstimulated (basal) release of radioactive material nor the release evoked by EFS. It was concluded that cisapride did not demonstrate a cholinomimetic effect in human sigmoid taenia coli muscle strips.

PubMed Disclaimer

References

    1. Can J Physiol Pharmacol. 1976 Feb;54(1):12-22 - PubMed
    1. Acta Physiol Scand. 1977 Nov;101(3):302-17 - PubMed
    1. Br J Pharmacol. 1978 Dec;64(4):565-80 - PubMed
    1. Br J Pharmacol Chemother. 1964 Aug;23:164-75 - PubMed
    1. Scand J Gastroenterol Suppl. 1984;92:8-12 - PubMed

Publication types

LinkOut - more resources