Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Aug 1;71(8):835-839.
doi: 10.1093/clinchem/hvaf028.

An Ambiguous NUDT15 Signal in a Child with B-cell Acute Lymphoblastic Leukemia

Affiliations

An Ambiguous NUDT15 Signal in a Child with B-cell Acute Lymphoblastic Leukemia

Rosalie M Sterner et al. Clin Chem. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Upon manuscript submission, all authors completed the author disclosure form.

Similar articles

References

    1. Weinshilboum RM, Sladek SL. Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity. Am J Hum Genet 1980;32:651–62. - PMC - PubMed
    1. Yang JJ, Landier W, Yang W, Liu C, Hageman L, Cheng C, et al. Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia. J Clin Oncol 2015;33:1235–42. - PMC - PubMed
    1. Moriyama T, Yang W, Smith C, Pui CH, Evans WE, Relling MV, et al. Comprehensive characterization of pharmacogenetic variants in TPMT and NUDT15 in children with acute lymphoblastic leukemia. Pharmacogenet Genomics 2022;32:60–6. - PMC - PubMed
    1. Pratt VM, Cavallari LH, Fulmer ML, Gaedigk A, Hachad H, Ji Y, et al. TPMT and NUDT15 genotyping recommendations: a joint consensus recommendation of the Association for Molecular Pathology, Clinical Pharmacogenetics Implementation Consortium, College of American Pathologists, Dutch Pharmacogenetics Working Group of the Royal Dutch Pharmacists Association, European Society for Pharmacogenomics and Personalized Therapy, and Pharmacogenomics Knowledgebase. J Mol Diagn 2022;24:1051–63. - PMC - PubMed
    1. Relling MV, Schwab M, Whirl-Carrillo M, Suarez-Kurtz G, Pui CH, Stein CM, et al. Clinical Pharmacogenetics Implementation Consortium guideline for thiopurine dosing based on TPMT and NUDT15 genotypes: 2018 update. Clin Pharmacol Ther 2019;105:1095–105. - PMC - PubMed

LinkOut - more resources