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. 1985 Nov;20(5):500-2.
doi: 10.1111/j.1365-2125.1985.tb05107.x.

Determinants of plasma alpha 1-acid glycoprotein (AAG) concentrations in health

P G Blain, J C Mucklow, M D Rawlins, D F Roberts, P A Routledge, D G Shand

Determinants of plasma alpha 1-acid glycoprotein (AAG) concentrations in health

P G Blain et al. Br J Clin Pharmacol. 1985 Nov.

Abstract

The concentration of alpha 1-acid glycoprotein (AAG) was measured in plasma from 200 healthy subjects belonging to 78 family units. The AAG concentration varied markedly between individuals (mean 0.77, range 0.36-1.46 g 1(-1]. When the genetic contribution to the variability was assessed, the only significant correlation observed was that between husband and wife and this was weak. We conclude that in addition to the known effects of age and gender, environmental (rather than genetic) factors largely determine the variance of AAG concentrations.

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