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Review
. 2025 Jul 24:2025:5526526.
doi: 10.1155/mi/5526526. eCollection 2025.

Drugs Used in the Treatment of Viral Infections for the Prevention of Airway Remodeling in Asthma

Joanna Wieczfinska  1 , Rafal Pawliczak  1
Affiliations
Review

Drugs Used in the Treatment of Viral Infections for the Prevention of Airway Remodeling in Asthma

Joanna Wieczfinska et al. Mediators Inflamm. .

Abstract

One of the main causes of the exacerbation of chronic airway inflammatory diseases is respiratory virus infections. The most prevalent viruses that can infect humans multiple times a year are rhinovirus (RV) and respiratory syncytial virus (RSV). Because remodeling factors like matrix metalloproteinases (MMPs), which are released by infiltrating neutrophils, are present. Airway remodeling is a characteristic of the pathology of airway diseases such as bronchial asthma. In these circumstances, viral infections may result in increased neutrophilic activation, which would exacerbate asthma symptoms and modify the airway. Although a connection between viral infections and acute exacerbations of chronic inflammatory respiratory diseases has been established, anti-inflammatory medications are frequently used in conjunction with antiviral medications to treat viral infections. Although their modes of action differ, they all lessen inflammation, which is essential for the development of airway remodeling. This review addresses the potential role of anti-inflammatory and antiviral drugs in preventing airway remodeling.

Keywords: airway remodeling; anti-inflammatory drugs; inflammation; viral infection.

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Conflict of interest statement

The authors declare no conflicts of interest.

References

    1. Tan K. S., Lim R. L., Liu J., et al. Respiratory Viral Infections in Exacerbation of Chronic Airway Inflammatory Diseases: Novel Mechanisms and Insights From the Upper Airway Epithelium. Frontiers in Cell and Developmental Biology . 2020;8 doi: 10.3389/fcell.2020.00099.99 - DOI - PMC - PubMed
    1. Moheimani F., Shahdab N., Cummings S., Hansbro P. M., Ward C. Key Role of Dysregulated Airway Epithelium in Response to Respiratory Viral Infections in Asthma. ERJ Open Research . 2022;8(3) doi: 10.1183/23120541.00314-2022.00314 - DOI - PMC - PubMed
    1. Pace E., Di Vincenzo S., Ferraro M., Lanata L., Scaglione F. Role of Airway Epithelium in Viral Respiratory Infections: Can Carbocysteine Prevent or Mitigate Them? Immunology . 2024;172(3):329–342. doi: 10.1111/imm.13762. - DOI - PubMed
    1. Varricchi G., Ferri S., Pepys J., et al. Biologics and Airway Remodeling in Severe Asthma. Allergy . 2022;77(12):3538–3552. doi: 10.1111/all.15473. - DOI - PMC - PubMed
    1. Banno A., Reddy A. T., Lakshmi S. P., Reddy R. C. Bidirectional Interaction of Airway Epithelial Remodeling and Inflammation in Asthma. Clinical Science . 2020;134(9):1063–1079. doi: 10.1042/CS20191309. - DOI - PubMed