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Review
. 2025 Jul 17:15:1537508.
doi: 10.3389/fonc.2025.1537508. eCollection 2025.

A bibliometric and visual analysis of Jak1 to explore trends and frontiers

Cong Yu #  1 , Jiamin Cao #  2 , Xiaodong Xie  1 , Wenguang Chen  1 , Ensi Hong  1   3
Affiliations
Review

A bibliometric and visual analysis of Jak1 to explore trends and frontiers

Cong Yu et al. Front Oncol. .

Abstract

Background: JAK1, a member of the JAK kinase family, is involved in the signal transduction of multiple cytokine pathways and is crucial in the onset and progression of inflammation and tumours. Consequently, JAK1 has garnered significant attention in recent years.

Methods: We use bibliometric and visual analysis to evaluate the thematic trends and knowledge structure of TRPV1's research papers on JAK1, sourced from the Web of Science core collection from 2003 to 2024. CiteSpace is used to analyze references and keywords of authors, institutions, countries, and commonly cited, and applies co-current and clustering functions to generate visual knowledge maps.

Results: A total of 3,686 articles were incorporated. The primary research domain of JAK1 is oncology; the United States leads in publication volume, with the University of Texas holding the most prominent central position. The keyword distribution indicates that the literature on JAK1 from 2003 to 2009 primarily concentrated on mechanistic studies, encompassing gene expression, activation, pathways, and cell apoptosis. From 2008 to 2018, research hotspots predominantly examined the association between JAK1 and various disease atlases. Beginning in 2012 and extending to 2024, the focus shifted towards the research and development of clinical pharmaceuticals, along with their safety and efficacy. Gene expression, signal transduction, atopic dermatitis, and JAK1-selective inhibitors have emerged as prominent research areas in recent years, exhibiting significant potential for development.

Conclusion: This study presents the contemporary status and prospective trends of JAK1 research over the last two decades. Current research focuses on skin inflammation, rheumatoid arthritis, and tumor-related diseases, while new signaling pathways are constantly being discovered. JAK1 inhibitors are gradually being used in clinical practice and have good development prospects, which will become the main trend of future research.

Keywords: bibliometric; citespace; jak1; research hotspots; visual analysis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Search flowchart.
Figure 2
Figure 2
(A) Annual publication trends in JAK1 research (2003–2024). X-axis: Year (2003–2024); Y-axis: Number of publications. The dashed line represents a polynomial trendline illustrating three growth phases. (B) Top 10 research fields of JAK1 research (2003–2024).
Figure 3
Figure 3
(A) Global collaboration network in JAK1 research (Citespace Analysis). (B) Top 10 countries by JAK1 publication volume (2003–2024).
Figure 4
Figure 4
A JAK1 field of issuing organisations cooperation network map (2003–2024).
Figure 5
Figure 5
A literature keyword co-occurrence map (2003–2024).
Figure 6
Figure 6
A keyword cluster analysis in the field of Jak1 (2003–2024).
Figure 7
Figure 7
(A) Keyword timeline chart (2003–2024). (B) Keywords with the strongest citation bursts (2003–2024).
See this image and copyright information in PMC

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References

    1. Gadina M, Chisolm DA, Philips RL, McInness IB, Changelian PS, O’Shea JJ. Translating JAKs to jakinibs. J Immunol. (2020) 204:2011–20. doi: 10.4049/jimmunol.1901477, PMID: - DOI - PubMed
    1. Spinelli FR, Colbert RA, Gadina M. JAK1: Number one in the family; number one in inflammation? Rheumatol (Oxford). (2021) 60:ii3–ii10. doi: 10.1093/rheumatology/keab024, PMID: - DOI - PMC - PubMed
    1. Horesh ME, Martin-Fernandez M, Gruber C, Buta S, Le Voyer T, Puzenat E, et al. Individuals with JAK1 variants are affected by syndromic features encompassing autoimmunity, atopy, colitis, and dermatitis. J Exp Med. (2024) 221(6):e20232387. doi: 10.1084/jem.20232387, PMID: - DOI - PMC - PubMed
    1. Li R, Liang Q, Yang Q, Dai W, Xiao Y, Pan H, et al. Hexahydrocurcumin from Zingiberis rhizoma attenuates lipopolysaccharide-induced acute pneumonia through JAK1/STAT3 signaling pathway. Phytomedicine. (2024) 122:155141. doi: 10.1016/j.phymed.2023.155141, PMID: - DOI - PubMed
    1. Xu H, Zhang X, Wang X, Li B, Yu H, Quan Y, et al. Cellular spermine targets JAK signaling to restrain cytokine-mediated autoimmunity. Immunity. (2024) 57:1796–1811.e8. doi: 10.1016/j.immuni.2024.05.025, PMID: - DOI - PubMed

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