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Published Erratum
. 2025 Jul 19;53(14):gkaf768.
doi: 10.1093/nar/gkaf768.

Correction to 'Selective disruption of an oncogenic mutant allele by CRISPR/Cas9 induces efficient tumor regression'

No authors listed
Published Erratum

Correction to 'Selective disruption of an oncogenic mutant allele by CRISPR/Cas9 induces efficient tumor regression'

No authors listed. Nucleic Acids Res. .
No abstract available

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Figures

Figure 4.
Figure 4.
Antitumor effect and survival benefit of adenoviral delivery of CRISPR/Cas9 to tumor xenograft models. (A) H1975 tumor-bearing mice were given intratumoral injections of PBS or 5 × 1010 VPs (Ad/Cas9 + Ad/empty vector or Ad/sgEGFR and Ad/Cas9) on days 1, 3 and 5. Tumor growth was monitored every other day until 31 days post injection. Values represent the mean ± S.E.M. for eight animals per group. ***P < 0.001 compared with the PBS and Ad/Cas9 treated groups. The percentage of surviving mice was determined by monitoring tumor growth-related events (tumor size < 800 mm3) over a time period. (B) A549 tumor-bearing mice were given intratumoral injections of PBS or 5 × 1010 Ad VPs (Ad/sgEGFR and Ad/Cas9) on days 1, 3 and 5. Tumor growth was monitored every other day until the end of the study. Bar represent the mean ± S.E.M. for eight animals per group. NS; not significant compared with the PBS treated groups. The percentage of surviving mice was determined by monitoring tumor growth-related events (tumor size < 800 mm3) over a time period. (C) PBS, Ad/Cas9 + Ad/empty vector or Ad/sgEGFR and Ad/Cas9 was injected on days 1, 3 and 5 into established H1975 tumors in nude mice. Tumors were harvested on day 7 for histological analysis. H & E staining and immunohistochemical staining of PCNA and EGFR were performed on tumor sections from each group of mice.
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References

    1. Yoon A, Hong J, Yun C A vesicular stomatitis virus glycoprotein epitope-incorporated oncolytic adenovirus overcomes CAR-dependency and shows markedly enhanced cancer cell killing and suppression of tumor growth. Oncotarget. 2015; 6:34875–91. 10.18632/oncotarget.5332. - DOI - PMC - PubMed

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