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. 1985 Sep;41(3):741-4.

Confidence limits for probability of response in multistage phase II clinical trials

E N Atkinson, B W Brown
  • PMID: 4074823

Confidence limits for probability of response in multistage phase II clinical trials

E N Atkinson et al. Biometrics. 1985 Sep.

Abstract

Herson (1979, Biometrics 35, 775-783) has given a method for designing one-arm k-stage phase II clinical trials, which permits early termination of the trial if the treatment is apparently ineffective, while retaining acceptable levels of power and significance. This paper gives a method for calculating the confidence limits on the response proportion, conditional on a particular study design.

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