[Microcirculatory system of hamsters under stress and following the prophylactic administration of ionol]

Abstract

Biomicroscopic studies of hamster pouches have shown that 1-24-hour immobilization and 3-hour electrical stimulation induced terminal blood flow slowing, erythrocyte aggregation, plasmatization and vessel stasis. 24-hour immobilization and 3-hour electrical stimulation enhanced globulin permeability of venular microvessels. All types of extremal stimulation increased mast cell degranulation. Preventive antioxidant (ionol) administration normalized vascular permeability and suppressed mast cell degranulation in stress-exposed animals.