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. 2025 Aug 1:ciaf421.
doi: 10.1093/cid/ciaf421. Online ahead of print.

All-Cause Mortality in People with Four-Class Drug-Resistant HIV: A Matched Cohort Analysis with Data from the PRESTIGIO Registry

Andrea Giacomelli  1   2 , Nicolò Capra  3 , Riccardo Lolatto  3 , Roberta Gagliardini  4 , Tommaso Clemente  3 , Leonardo Calza  5 , Carlo Torti  6 , Filippo Lagi  7 , Chiara Fornabaio  8 , Giulia Marchetti  9 , Giancarlo Orofino  10 , Vincenzo Spagnuolo  3   11
Affiliations
Free article

All-Cause Mortality in People with Four-Class Drug-Resistant HIV: A Matched Cohort Analysis with Data from the PRESTIGIO Registry

Andrea Giacomelli et al. Clin Infect Dis. .
Free article

Abstract

People with HIV (PWH) with four-drug class resistance (4DR) had a higher risk of death than non-4DR PWH, primarily due to lower CD4 cell counts. The priority for this vulnerable population is achieving virological control to enable immune recovery.

Keywords: death; heavily treatment experienced; immune suppression; multi drug resistance; outcome.

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